IRS1 gene polymorphisms Gly972Arg and Ala513Pro are not associated with insulin resistance and type 2 diabetes risk in non-obese Turkish population

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dc.contributor.authorArıkoğlu, Hilal
dc.contributor.authorHepdoğru, Melda Aksoy
dc.contributor.authorKaya, Dudu Erkoç
dc.contributor.authorAşık, Aycan
dc.contributor.authorİpekçi, Süleyman Hilmi
dc.contributor.authorİşçioğlu, Funda
dc.date.accessioned2020-03-26T18:59:09Z
dc.date.available2020-03-26T18:59:09Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractInsulin receptor substrate 1 (IRS1), plays a critical role in insulin signaling and its control has an important place in the development of insulin resistance. The tyrosine phosphorylation of IRS1 serves as docking molecules for downstream effectors such as Phosphatidylinositol 3-kinase and phosphotyrosine phosphatase-2. We focused on the Gly972Arg and Ala513Pro variants of the IRS1 gene, since these specific allelic variants are located near the Tyr-Met-X-Met (YMXM) motifs around Tyr987 and Tyr612. Thus, we aimed to investigate the effects of Gly972Arg/Ala513Pro polymorphisms in IRS1 gene on development of insulin resistance and the risk of type 2 diabetes in a non-obese Turkish population. This work included 306 individuals comprising 178 subjects with type 2 diabetes and 128 healthy subjects matched for body mass index. Gly972Arg/Ala513Pro polymorphisms had no effect on type 2 diabetes risk and its phenotypes (P. > 0.05). Although IRS1 gene and its variants are associated with type 2 diabetes and insulin resistance in several studies worldwide, our data showed that there is no association between Gly972Arg and Ala513Pro variants in IRS1 and disease in Turkish population. © 2014.en_US
dc.description.sponsorship2003/010en_US
dc.description.sponsorshipWe would like to thank to Dr. Ahmet Arslan and Dr. Mustafa Sait Gonen for their assistance in this study. This study was supported by the Selcuk University Research Foundation (2003/010).en_US
dc.identifier.doi10.1016/j.mgene.2014.07.008en_US
dc.identifier.endpage585en_US
dc.identifier.issn2214-5400en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage579en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.mgene.2014.07.008
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31432
dc.identifier.volume2en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMeta Geneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectIRS1 geneen_US
dc.subjectI?nsulin resistanceen_US
dc.subjectPolymorphismsen_US
dc.subjectType 2 diabetesen_US
dc.titleIRS1 gene polymorphisms Gly972Arg and Ala513Pro are not associated with insulin resistance and type 2 diabetes risk in non-obese Turkish populationen_US
dc.typeArticleen_US

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