Diagnostic and Prognostic Value of Lipopolysaccharide Binding Protein and Soluble Urokinase Plasminogen Activator Receptor in Dogs with Parvoviral Enteritis
Yükleniyor...
Dosyalar
Tarih
2023 Mart
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Selçuk Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmada, parvoviral enteritisli köpeklerde lipopolisakkarit bağlayıcı protein (LBP) ve soluble ürokinaz plazminojen aktivatör reseptörünün (suPAR) tanısal ve prognostik değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Bu çalışmanın hayvan materyalini 1-6 ay yaşlar arasında farklı ırk ve cinsiyette kanlı ishal semptomu gösteren hızlı test kiti yardımıyla parvoviral enteritis teşhisi konulan 20 köpek hasta grubunu oluşturdu. Kontrol amacıyla kliniğe getirilen ve yapılan fiziksel muayeneler sonucunda sağlıklı olduğu belirlenen 10 köpek kontrol grubunu oluşturdu. Çalışmadaki köpeklerin tamamından bir defa Vena cephalica antebrachi’den kan örnekleri alındı. Alınan örnekten tam kan hücresi sayımı yapıldı. Serum örneklerinden serum biyokimyasal analizleri yapıldı. Bulgular: Serum örnekleri ise biyokimyasal ölçümler yapılana kadar -20°C’de muhafaza edildi. Hematoloji bulgularında hasta grupta total lökosit sayısı, eritrosit sayısı, hemoglobin sayısı ve hematokrit yüzdesi kontrol grubuna kıyasla istatistiksel olarak anlamlı düşük bulundu (p<0,05). Hasta grupta kreatinin (p=0,040), üre (p=0,036), total bilirubin (p=0,011), seruloplazmin (p=0,008), haptoglobin (p<0,001) ve LBP (p=0,011) konsantrasyonları kontrol grubuna göre istatistiksel olarak anlamlı yüksek bulurken, albümin (p=0,005) ve suPAR (p=0,012) konsantrasyonları düşük bulunmuştur. Öneri: Sonuç olarak parvoviral enteritisli köpeklerde seruloplazmin, haptoglobin, LBP ve suPAR diagnostik ve prognostik olarak önemli bulunmuştur.
Aim: The aim of this study was to evaluate the diagnostic and prognostic values of lipopolysaccharide binding protein (LBP) and soluble urokinase plasminogen activator receptor (suPAR) in dogs with parvoviral enteritis (CPV). Materials and Methods: Twenty dogs, 1-6 months old, from different breeds and genders were enrolled in the study. The presence of parvoviral enteritis confirmed by rapid test kit and ongoing bloody diarrhea. Ten healthy age matched dogs were enrolled in the study as control group. Blood samples were taken once from all of the dogs from Vena cephalica antebrachi. A complete blood cell count was measured from taken sample. Serum biochemical analyses were performed from the serum samples Results: Total leukocyte count, erythrocyte count, hemoglobin count and hematocrit percentage were significantly lower in the dogs with CPV compared to the control group (p<0.05). While creatinine (p=0.040), urea (p=0.036), total bilirubin (p=0.011), ceruloplasmin (p=0.008), haptoglobin (p<0.001) and LBP (p=0.011) concentrations were significantly higher in the dogs with CPV compared to the control group, albumin (p=0.005) and suPAR (p=0.012) concentrations were found to be low. Conclusion: Ceruloplasmin, haptoglobin, LBP and suPAR were found to be diagnostically and prognostically important in dogs with parvoviral enteritis.
Aim: The aim of this study was to evaluate the diagnostic and prognostic values of lipopolysaccharide binding protein (LBP) and soluble urokinase plasminogen activator receptor (suPAR) in dogs with parvoviral enteritis (CPV). Materials and Methods: Twenty dogs, 1-6 months old, from different breeds and genders were enrolled in the study. The presence of parvoviral enteritis confirmed by rapid test kit and ongoing bloody diarrhea. Ten healthy age matched dogs were enrolled in the study as control group. Blood samples were taken once from all of the dogs from Vena cephalica antebrachi. A complete blood cell count was measured from taken sample. Serum biochemical analyses were performed from the serum samples Results: Total leukocyte count, erythrocyte count, hemoglobin count and hematocrit percentage were significantly lower in the dogs with CPV compared to the control group (p<0.05). While creatinine (p=0.040), urea (p=0.036), total bilirubin (p=0.011), ceruloplasmin (p=0.008), haptoglobin (p<0.001) and LBP (p=0.011) concentrations were significantly higher in the dogs with CPV compared to the control group, albumin (p=0.005) and suPAR (p=0.012) concentrations were found to be low. Conclusion: Ceruloplasmin, haptoglobin, LBP and suPAR were found to be diagnostically and prognostically important in dogs with parvoviral enteritis.
Açıklama
Anahtar Kelimeler
Köpek, LBP, parvoviral enteritis, suPAR, Dog
Kaynak
Eurasian Journal of Veterinary Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
39
Sayı
1
Künye
Gucsav, A. B., Akyuz, E., (2023). Diagnostic and Prognostic Value of Lipopolysaccharide Binding Protein and Soluble Urokinase Plasminogen Activator Receptor in Dogs with Parvoviral Enteritis. Eurasian Journal of Veterinary Sciences, 39(1), 37-45.
DOI: 10.15312/EurasianJVetSci.2023.397
