Antibody responses against foot-and-mouth disease vaccine differ between the sexes in cattle
Yükleniyor...
Dosyalar
Tarih
2013
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Selçuk Üniversitesi Veterinerlik Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Sığırlarda şap virusuna karşı aşılamaya bağlı gelişen humoral immun yanıt üzerine cinsiyetin etkisinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Sığırlar (n=252) yaşlarına (0-11 ay, 12-35 ay ve >35 ay) ve cinsiyetlerine (erkek-dişi) göre 6 gruba ayrıldı. Her bir gruptaki hayvanlar yağ adjuvantlı bivalent (O1 Manisa, A22 Irak suşları) aşı ile aşılandı. Aşılanan sığırlardaki antikor yanıtı solid faz kompetitif ELISA ile belirlendi. Bulgular: Yüz yirmi altı erkek serumunun, 86 (%68.2)’sında serotip O, 90 (%71.4)’ında serotip A’ya karşı antikor tespit edildi. Dişi hayvanlarda ise 126 serumun 106 (%84.1)’sında serotip O, 112 (%88.8)’sinde serotip A’ya karşı oluşan antikor tespit edildi. Dişi serumlarının 89 (%70.6)’unda serotip O, 98 (%77.7)’sinde serotip A’ya karşı koruyucu düzeyde antikor yanıtı belirlendi. Erkek sığır serumlarının ise 67 (%53.1)’sinde serotip O, 81 (%64.2)’inde serotip A’ya karşı koruyucu düzeyde antikor varlığı tespit edildi. Dişi ve erkek hayvanlar arasında hem serotip O (P=0.0063) hem de serotip A (P=0.0259)’ya karşı koruyucu düzey antikor yanıtları arasındaki farklılık istatiksel olarak önemli bulundu. Öneri: Sonuçlar yağ adjuvantlı bivalent (O1 Manisa, A22 Irak suşları) aşı ile aşılanan dişi hayvanların, erkek hayvanlardan daha yüksek antikor yanıtlarına sahip olduğunu göstermektedir. Dişi ve erkek hayvanlar arasında şap aşılamasına bağlı gelişen immun yanıt farklılığının aydınlatılması için daha fazla çalışmaya ihtiyaç vardır.
Aim: The aim of this study was to investigate the effects of sex on the humoral immune response induced in cattle by vaccination against foot-and-mouth disease virus (FMVD). Materials and Methods: Cattle (n=252) were classified into six groups according to the age (0-11 months, 12-35 months, and >35 months) and sex (male-female). Animals in each group were vaccinated with oil-adjuvanted bivalent vaccine (O1 Manisa, A22 Iraq FMDV strains). Solid-phase competitive ELISA was used to measure antibodies produced in vaccinated cattle. Results: Serotype O antibody was detected in 86 (68.2%) and serotype A antibody in 90 (71.4%) of 126 male sera. In female animals, serotype O antibody was detected in 106 (84.1%) and serotype A antibody in 112 (88.8%) of 126 sera. Protective level of antibody against serotype O was detected in 89 (70.6%) and serotype A in 98 (77.7%) of 126 female sera. Protective level of antibody against serotype O antibody was detected in 67 (53.1%) and serotype A in 81 (64.2%) of 126 male sera. The differences between the level of protective antibody against both serotype O (P=0.0063) and serotype A (P=0.0259) in female and male animals were statistically significant. Conclusions: Results showed that female animals vaccinated with oil-adjuvanted bivalent vaccine (containing O1 Manisa, A22 Iraq FMDV strains) had higher antibody responses than male animals. In order to elucidate difference between immune response of male and female animals to FMD vaccination more studies are needed.
Aim: The aim of this study was to investigate the effects of sex on the humoral immune response induced in cattle by vaccination against foot-and-mouth disease virus (FMVD). Materials and Methods: Cattle (n=252) were classified into six groups according to the age (0-11 months, 12-35 months, and >35 months) and sex (male-female). Animals in each group were vaccinated with oil-adjuvanted bivalent vaccine (O1 Manisa, A22 Iraq FMDV strains). Solid-phase competitive ELISA was used to measure antibodies produced in vaccinated cattle. Results: Serotype O antibody was detected in 86 (68.2%) and serotype A antibody in 90 (71.4%) of 126 male sera. In female animals, serotype O antibody was detected in 106 (84.1%) and serotype A antibody in 112 (88.8%) of 126 sera. Protective level of antibody against serotype O was detected in 89 (70.6%) and serotype A in 98 (77.7%) of 126 female sera. Protective level of antibody against serotype O antibody was detected in 67 (53.1%) and serotype A in 81 (64.2%) of 126 male sera. The differences between the level of protective antibody against both serotype O (P=0.0063) and serotype A (P=0.0259) in female and male animals were statistically significant. Conclusions: Results showed that female animals vaccinated with oil-adjuvanted bivalent vaccine (containing O1 Manisa, A22 Iraq FMDV strains) had higher antibody responses than male animals. In order to elucidate difference between immune response of male and female animals to FMD vaccination more studies are needed.
Açıklama
Anahtar Kelimeler
Şap hastalığı, sığır, cinsiyet, aşılama, antikor yanıtı, Foot and mouth disease, cattle, vaccination, sex, antibody response
Kaynak
Eurasian Journal Of Veterinary Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
29
Sayı
4
Künye
Şevik, M., (2013).Antibody responses against foot-and-mouth disease vaccine differ between the sexes in cattle. Eurasian Journal Of Veterinary Sciences, 29 (4), 205-2010.
