Anti-diabetic and anti-hyperlipidemic properties of Capparis spinosa L.: In vivo and in vitro evaluation of its nutraceutical potential

Basit Öğe Kaydı
dc.contributor.authorMollica, Adriano
dc.contributor.authorZengin, Gökhan
dc.contributor.authorLocatelli, Marcello
dc.contributor.authorStefanucci, Azzurra
dc.contributor.authorMocan, Andrei
dc.contributor.authorMacedonio, Giorgia
dc.contributor.authorCarradori, Simone
dc.date.accessioned2020-03-26T19:33:53Z
dc.date.available2020-03-26T19:33:53Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn this study, the nutraceutical potential of Capparis spinosa L for the treatment of hyperglycemic states has been thoroughly investigated. A series of in vivo and in vitro tests have been conducted on fresh leaf, buds and salty buds (24 h desalted) processed to dry powder. 60% MeOH/H2O extracts were obtained for HPLC analysis and for alpha-amylase and alpha-glucosidase inhibition tests. To estimate the in vivo anti-diabetic effect, dry powders of C spinosa leaf and buds were orally administered to streptozocin-induced diabetic rats over a period of 28 days. At the end of the experiment, animals were sacrificed, blood taken for assessment of lipid profile and liver/kidney biochemistry while section of the pancreas, liver and kidneys were processed for general histology. Results showed that the regular administration of C. spinosa leaf or buds normalized all the biochemical parameters and reversed the liver/kidney injury with variable degrees of organ protection. (C) 2017 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.jff.2017.05.001en_US
dc.identifier.endpage42en_US
dc.identifier.issn1756-4646en_US
dc.identifier.startpage32en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jff.2017.05.001
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34803
dc.identifier.volume35en_US
dc.identifier.wosWOS:000406080900005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofJOURNAL OF FUNCTIONAL FOODSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectalpha-Amylaseen_US
dc.subjectalpha-Glucosidaseen_US
dc.subjectNutraceuticalsen_US
dc.subjectHPLCen_US
dc.subjectPolyphenolsen_US
dc.subjectFlavonoidsen_US
dc.subjectCapparis spinosa L.en_US
dc.subjectDiabetesen_US
dc.titleAnti-diabetic and anti-hyperlipidemic properties of Capparis spinosa L.: In vivo and in vitro evaluation of its nutraceutical potentialen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu