Development of paclitaxel and flurbiprofen co-loaded PLGA nanoparticles: understanding critical formulation and process parameters using Plackett-Burman design

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dc.authorid0000-0002-3996-2931
dc.authorid0000-0002-3189-2377
dc.authorid0000-0001-5510-8973
dc.authorid0000-0003-4648-3258
dc.authorid0000-0002-3427-6078
dc.authorid0000-0003-1234-9018
dc.contributor.authorŞahin, Adem
dc.contributor.authorToktaş, Seçil Çaban
dc.contributor.authorTonbul, Hayrettin
dc.contributor.authorYerlikaya, Fırat
dc.contributor.authorAktaş, Yeşim
dc.contributor.authorÇapan, Yılmaz
dc.date.accessioned2020-03-26T20:13:24Z
dc.date.available2020-03-26T20:13:24Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümüen_US
dc.description.abstractNano drug co-delivery system is a popular strategy for combined application of two or more anticancer and/or synergistic drugs. Synergistic effects of nonsteroidal anti-inflammatory drugs and anti-cancer drugs in cancer treatment are shown in the literature. This study aimed to screen and understand the critical formulation and process parameters in the preparation of flurbiprofen and paclitaxel co-loaded nanoparticles to develop an anti-cancer nano co-delivery system. With this aim, critical parameters were determined using the Plackett-Burman experimental design (DoE). Flurbiprofen and paclitaxel drug loading amounts were considered as critical quality attributes to control the effective drug loading ratio. Furthermore, average particle size and zeta potential were also defined as critical quality attributes in order to optimize passive drug targeting and colloidal stability. Surfactant type was determined as the most significant factor for the average particle size and zeta potential. For flurbiprofen and paclitaxel drug loading into the nanoparticles, amounts of both flurbiprofen and paclitaxel were determined as critical factors. Consequently, paclitaxel and flurbiprofen were efficiently loaded into nanoparticles, and the impact of the formulation variables was successfully screened by a DoE. By controlling the determined parameters, the therapeutic efficacy of co-loaded drug nanoparticles could be maximized in further studies.en_US
dc.description.sponsorshipHacettepe University Scientific Research Projects Coordination UnitHacettepe University [014 D07 301 004-669]en_US
dc.description.sponsorshipThis research was supported by Hacettepe University Scientific Research Projects Coordination Unit [grant numbers: 014 D07 301 004-669].en_US
dc.identifier.citationŞahin, A., Toktaş, S. Ç., Tonbul, H., Yerlikaya, F., Aktaş, Y., Çapan, Y. (2019). Development of Paclitaxel and Flurbiprofen Coloaded PLGA Nanoparticles: Understanding Critical Formulation and Process Parameters Using Plackett–Burman Design. İstanbul Journal of Pharmacy, 49(3), 161-166.
dc.identifier.doi10.26650/IstanbulJPharm.2019.19036en_US
dc.identifier.endpage166en_US
dc.identifier.issn0367-7524en_US
dc.identifier.issn2548-0731en_US
dc.identifier.issue3en_US
dc.identifier.pmid#YOKen_US
dc.identifier.startpage161en_US
dc.identifier.urihttps://dx.doi.org/10.26650/IstanbulJPharm.2019.19036
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37686
dc.identifier.volume49en_US
dc.identifier.wosWOS:000511129700008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorŞahin, Adem.
dc.language.isoenen_US
dc.publisherISTANBUL UNIV, FAC PHARMACYen_US
dc.relation.ispartofISTANBUL JOURNAL OF PHARMACYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectNanoparticlesen_US
dc.subjectpaclitaxelen_US
dc.subjectflurbiprofenen_US
dc.subjectPLGAen_US
dc.subjectdesign of experimentsen_US
dc.subjectPlackett-Burmanen_US
dc.titleDevelopment of paclitaxel and flurbiprofen co-loaded PLGA nanoparticles: understanding critical formulation and process parameters using Plackett-Burman designen_US
dc.typeArticleen_US

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