CD19 deficiency: A village screening study

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dc.contributor.authorReisli, İsmail
dc.contributor.authorArtaç, Hasibe
dc.contributor.authorPekcan, Sevgi
dc.contributor.authorKara, Reyhan
dc.contributor.authorYumlu, Kadir
dc.contributor.authorKaragöl, Cüneyt
dc.contributor.authorÇimen, Ömer
dc.date.accessioned2020-03-26T17:38:00Z
dc.date.available2020-03-26T17:38:00Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim: We identified a new CD19 deficient case who was a relative of the first CD19 deficient patient and lived in the same village. These cases suggested that other patients with CD19 deficiency or carriers could be found in this village. The aim of this study was to assess the warning signs of primary immunodeficiency and the CD19 molecule deficiency in this population. Material and Method: The relatives of CD19 deficient patients and controls were examined for the warning signs of primary immunodeficiency using a questionnaire form Blood samples were taken from these subjects CD19 and CD21 expressions (median fluorescent intensity, MFI) were analyzed by flowcytometry in these samples. Results: A total of 208 subjects (59 families, 126 females, 82 males) including 129 children 9.5 +/- 3 7 years and 79 adults (37 13 years) were evaluated. A new case with CD19 deficiency was not detected There was at least one warning sign for immunodeficiency in 67 subjects (57 children and 10 adults) CD19 median expression value was lower than 60 MFI value in 20 subjects, which was known as in the carriers who were detected to have heterozygous mutation Conclusions: Our findings suggested that CD19 median expression might be a diagnostic tool for the subjects who have CD19 heterozygous mutations. Mutation analyses are planned for the confirmation of CD19 heterozygous mutation in these subjects who have low CD19 median expression. (Turk Arch Ped 2009; 44. 127-30)en_US
dc.identifier.endpage130en_US
dc.identifier.issn1306-0015en_US
dc.identifier.issn1308-6278en_US
dc.identifier.issue4en_US
dc.identifier.startpage127en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23336
dc.identifier.volume44en_US
dc.identifier.wosWOS:000272580400006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherAVESen_US
dc.relation.ispartofTURK PEDIATRI ARSIVI-TURKISH ARCHIVES OF PEDIATRICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectA village screeningen_US
dc.subjectCD19 deficiencyen_US
dc.subjectCD19 median expressionen_US
dc.titleCD19 deficiency: A village screening studyen_US
dc.typeArticleen_US

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