Effect of deferoxamine on Na+K+ATPase activity after cerebral ischemia in rabbits

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dc.contributor.authorGürbilek, Mehmet
dc.contributor.authorTopcu, Cemile
dc.contributor.authorAköz, Mehmet
dc.contributor.authorBarışkaner, Hülagü
dc.contributor.authorÜstün, Mehmet E.
dc.contributor.authorKöylü, Öznur
dc.date.accessioned2020-03-26T17:05:14Z
dc.date.available2020-03-26T17:05:14Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: To study the effects of deferoxamine on tissue sodium-potassium adenosine triphosphatase (Na+-K+ ATPase) activity on cerebral ischemia in rabbits. Methods: We cared for the animals in the Pharmacology Department of the Medical School of Selcuk University in 2004. We used 30, New Zealand, 7-day-old male rabbits in the experiment. We anesthetized all the animals with xylazine hydrochloric acid and ketamine. We divided the rabbits equally into 3 groups. In group 1 (n=10) (sham group), we observed baseline levels, and did not apply ischemia. In group 2 (n=10) (untreated group) we produced cerebral ischemia by clamping the bilateral common carotid arteries for 60 minutes, and in group 3 (n=10), we administered deferoxamine (DFO) 50 mg/kg intravenously immediately after opening the clamps. Results: The Na +-K+ATPase activity increased after DFO treatment (p=0.045). Conclusion: We conclude that Na+-K+ATPase activity in cortical brain tissue was higher in DFO-treated rabbits compared with untreated animals after ischemia.en_US
dc.identifier.endpage92en_US
dc.identifier.issn1319-6138en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage88en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20865
dc.identifier.volume11en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofNeurosciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleEffect of deferoxamine on Na+K+ATPase activity after cerebral ischemia in rabbitsen_US
dc.typeArticleen_US

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