Effects of Aprotinin on Pulmonary Functions in Experimental Fat Embolism: Changes in Arterial Blood Gas Levels and Scintigraphic Findings

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dc.contributor.authorYel, Mustafa
dc.contributor.authorDalgıç, Hülya
dc.contributor.authorTaştekin, Güngör
dc.contributor.authorArazi, Mehmet
dc.contributor.authorKutlu, Abdurrahman
dc.date.accessioned2020-03-26T16:36:26Z
dc.date.available2020-03-26T16:36:26Z
dc.date.issued2000
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose: To assess the effects of aprotinin on the formation and resolution of fat embolism of the lungs. Methods: The changes in arterial blood gas levels and perfusion scintigraphy were studied by forming experimental standardized fat embolism in rabbits with autogenous fat obtained from their femur medullas. Two groups, each consisting of 14 albino rabbits, were used in this study. Group 1, which received intravenous saline solution, was the control group. Group 2, which received aprotinin, was referred to as the aprotinin group. Autogenous femoral medullary content was used for embolization procedures. Arterial blood gas levels were recorded 72 hours before and 1, 24, 72 hours and 10 days following the embolization procedure. Pulmonary perfusion scintigraphies were performed 72 hours before the embolization procedure and on the first and 72nd hours, and the 10th day. Results: Fat embolism was achieved in all rabbits. Seven rabbits in the control group and one rabbit in the aprotinin group died within an hour after the embolization procedure. According to blood gas levels and perfusion scintigraphic findings, the aprotinin group significantly had less pulmonary fat embolism and recovered faster than the control group, especially during the first 24 hours. There was no significant difference in regression of pulmonary dysfunction between the two groups. Conclusion: The correlation between the blood gas levels and scintigraphic findings suggested that the administration of aprotinin for prophylactic purposes had favorable effects on the development of pulmonary gas exchange disturbance and perfusion defect in fat embolism.en_US
dc.identifier.citationYel, M., Dalgıç, H., Taştekin, G., Arazi, M., Kutlu, A., (2000). Effects of Aprotinin on Pulmonary Functions in Experimental Fat Embolism: Changes in Arterial Blood Gas Levels and Scintigraphic Findings. Journal of Musculoskeletal Research, 4(3), 189-198. Doi: 10.1016/S0218-9577(00)00019-7
dc.identifier.doi10.1016/S0218-9577(00)00019-7en_US
dc.identifier.endpage198en_US
dc.identifier.issn0218-9577en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage189en_US
dc.identifier.urihttps://dx.doi.org/10.1016/S0218-9577(00)00019-7
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17301
dc.identifier.volume4en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorYel, Mustafa
dc.institutionauthorDalgıç, Hülya
dc.institutionauthorTaştekin, Güngör
dc.institutionauthorArazi, Mehmet
dc.institutionauthorKutlu, Abdurrahman
dc.language.isoenen_US
dc.relation.ispartofJournal of Musculoskeletal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAprotininen_US
dc.subjectFat embolismen_US
dc.subjectPulmonary insufficiencyen_US
dc.titleEffects of Aprotinin on Pulmonary Functions in Experimental Fat Embolism: Changes in Arterial Blood Gas Levels and Scintigraphic Findingsen_US
dc.typeArticleen_US

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