Pyometralı köpeklerde laktat dehidrogenaz, tam kan ve bazı serum biyokimya parametreleri arasındaki ilişkinin değerlendirilmesi
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Tarih
2020
Yazarlar
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Yayıncı
Selçuk Üniversitesi Veteriner Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmanın amacı, pyometralı köpeklerde serum biyokimya ve tam kan parametrelerinin değerlendirilmesi ve laktat dehidrogenaz ile bu parametreler arasındaki ilişkinin tespit edilmesidir. Gereç ve Yöntem: Çalışmada; 6-14 yaş arası, farklı ırklarda toplam 26 adet dişi köpek kullanıldı. Pyometralı köpeklerin (n=20) teşhisi, anamnez, klinik ve ultrasonografik muayene ile konuldu. Kontrol grubundaki (n=6) köpekler ise kliniğe çeşitli nedenlerle (genital organ muayenesi vb) getirilen >6 yaşlı sağlıklı hayvanlar arasından seçildi. Her iki gruptaki köpeklerden tam kan ve serum biyokimya parametrelerini değerlendirmek amacıyla V. cephalica’dan kan örneği alındı. Bulgular: Pyometra grubundaki köpeklerde; WBC, nötrofil ve monosit değerlerinin kontrol grubuna göre daha yüksek olduğu (p<0,05), RBC ve lenfosit değerlerinin ise daha düşük olduğu tespit edildi (p<0,05). Pyometralı köpeklerde üre, ALP ve LDH seviyelerinin daha yüksek, albümin değerlerinin ise daha düşük olduğu belirlendi (p<0,05). Bununla birlikte kapalı serviks pyometralı köpeklerde tam kan ve serum biyokimya sonuçlarının, açık serviks pyometralı köpeklere göre daha fazla etkilendiği görüldü. Ayrıca, LDH düzeyleri hem açık hem de kapalı serviks pyometralı köpeklerde normal değerlerden oldukça yüksek bulundu. Pyometralı köpeklerin LDH seviyesi ile WBC, kreatinin, ALT, AST, ALP, CK arasında güçlü pozitif korelasyon (p<0,05) ve LDH ile RBC ve albümin arasında ise negatif korelasyon belirlendi (p>0,05). Öneri: Sonuç olarak pyometralı köpeklerde WBC ve nötrofil sayılarının oldukça fazla arttığı, böbrek ve karaciğer fonksiyonlarının etkilendiği tespit edilmiştir. Ayrıca kapalı serviks pyometralı köpeklerde sistemik sorunların daha ciddi seyrettiği belirlenmiştir. Bununla birlikte LDH seviyesinin böbrek ve karaciğer enzimleri ile korelasyon halinde olması nedeniyle pyometralı köpeklerde LDH seviyesinin ölçülmesinin prognozun belirlenmesinde faydalı olabileceği kanısına varılmıştır.
Aim: Objectives of this study were to evaluate serum biochemistry and complete blood parameters in bitches with pyometra and to determine the relationship between lactate dehydrogenase and these parameters. Materials and Methods: A total of 26 bitches with different breeds, 6-14 aged, were used in the study. The bitches with pyometra (n = 20) were diagnosed by anamnesis, clinical and ultrasonographical examination. The bitches in the control group (n = 6) were selected from >6 years old healthy animals brought to the clinic for various reasons (genital organ examination, etc.). A blood sample was taken from V. cephalica to evaluate the parameters of complete blood count and serum biochemistry from bitches in both groups. Results: It was determined that WBC, neutrophil and monocyte values were higher (p<0.05), and RBC and lymphocyte values were lower (p<0.05) in bitches in the pyometra group than the control group. Urea, ALP and LDH concentrations were higher and albumin concentrations were lower in bitches with pyometra (p<0.05). Moreover, it was found that the results of complete blood count and serum biochemical parameters in bitches with closed cervix pyometra were more affected than bitches with open cervix pyometra. In addition, LDH concentrations were found to be significantly higher than reference values in bitches with both open and closed cervix pyometra. Strong positive correlation (p<0.05) was determined between the LDH concentrations and WBC, creatinine, ALT, AST, ALP, CK and negative correlation (p>0.05) was determined between LDH and RBC and albumin in bitches with pyometra. Conclusion: As a result, it was found that WBC and neutrophils increased significantly in bitches with pyometra and kidney and liver functions were affected adversely. In addition, it has been determined that systemic problems were more serious in bitches with closed cervix pyometra. However, since LDH concentrations were correlated with kidney and liver enzymes, it was concluded that measuring LDH concentrations in bitches with pyometra may be useful in determining the prognosis.
Aim: Objectives of this study were to evaluate serum biochemistry and complete blood parameters in bitches with pyometra and to determine the relationship between lactate dehydrogenase and these parameters. Materials and Methods: A total of 26 bitches with different breeds, 6-14 aged, were used in the study. The bitches with pyometra (n = 20) were diagnosed by anamnesis, clinical and ultrasonographical examination. The bitches in the control group (n = 6) were selected from >6 years old healthy animals brought to the clinic for various reasons (genital organ examination, etc.). A blood sample was taken from V. cephalica to evaluate the parameters of complete blood count and serum biochemistry from bitches in both groups. Results: It was determined that WBC, neutrophil and monocyte values were higher (p<0.05), and RBC and lymphocyte values were lower (p<0.05) in bitches in the pyometra group than the control group. Urea, ALP and LDH concentrations were higher and albumin concentrations were lower in bitches with pyometra (p<0.05). Moreover, it was found that the results of complete blood count and serum biochemical parameters in bitches with closed cervix pyometra were more affected than bitches with open cervix pyometra. In addition, LDH concentrations were found to be significantly higher than reference values in bitches with both open and closed cervix pyometra. Strong positive correlation (p<0.05) was determined between the LDH concentrations and WBC, creatinine, ALT, AST, ALP, CK and negative correlation (p>0.05) was determined between LDH and RBC and albumin in bitches with pyometra. Conclusion: As a result, it was found that WBC and neutrophils increased significantly in bitches with pyometra and kidney and liver functions were affected adversely. In addition, it has been determined that systemic problems were more serious in bitches with closed cervix pyometra. However, since LDH concentrations were correlated with kidney and liver enzymes, it was concluded that measuring LDH concentrations in bitches with pyometra may be useful in determining the prognosis.
Açıklama
Anahtar Kelimeler
Pyometra, Köpek, Laktat dehidrogenaz, Kan parametreleri, Pyometra, Bitch, Lactate dehydrogenase, Blood parameters
Kaynak
Eurasian Journal of Veterinary Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
36
Sayı
3
Künye
Karakaş Alkan, K., Çiftçi, M. F., Yeşilkaya, Ö. F., Satılmış, F., Tekindal, M. A., Alkan, H., (2020).Pyometralı köpeklerde laktat dehidrogenaz, tam kan ve bazı serum biyokimya parametreleri arasındaki ilişkinin değerlendirilmesi. Eurasian Journal of Veterinary Sciences, 36 (3), 204-213. DOI: 10.15312/EurasianJVetSci.2020.280
