Effects of the Trans-9 18:1 Octadecenoic Acid Isomer on Rat Liver Membrane Na+/K+ ATPase Enzyme Activity Plasma Lipoproteins
Küçük Resim Yok
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: The consumption of trans-fatty acids is associated with increasing coronary heart disease risk. When oils are partially hydrogenised to margarine form, trans isomers of fatty acids are formed. In this study we investigated the effects of dietary trans-9 18:1 octadecenoic acid isomer on liver cell membrane Na+/K+ ATPase enzyme activity, fat composition and lipid metabolism. Method and Material: This study was conducted on two groups of rats, study and control. Study group was given 50 mg/day trans-9 18:1 octadecenoic acid isomers for ten days. Fatty acid composition of serum and liver tissue was analyzed using gas chromatography Results: Study group showed trans-9 18:1 fatty acid presence while control group did not, thus trans-9 18:1 octadecenoic acid isomer is not a naturally occurring compound. The meaningful increase of C18:2 6n fatty acid and meaningful decrease of C20:4 6n in study group show that trans-9 18:1 octadecenoic acid isomers affected desaturation activity and prevented C18:2 6n fatty acid from turning into C20:4 6n. Rats fed with trans-9 18:1 octadecenoic acid showed decreased HDL and HDL2 cholesterol levels. No change was observed in HDL3, LDL, total cholesterol, triglyceride and Na+/K+ ATPase activity. Our findings combined with current literature allow us to conclude; sine TFAs change serum HDL and HDL2 cholesterol levels, nutrition's containing TFA may increase the risk of heart disease. 2010 © TurkJBiochem.com.
Açıklama
Anahtar Kelimeler
Lipoproteins, NA+/K+ ATPase, Trans-9 18:1 octadecenoic acid
Kaynak
Turkish Journal of Biochemistry
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
35
Sayı
2
