Ürik Asitin Koroner Arter Hastalığı, Yaygınlığı ve Risk Faktörleri İle İlişkisi
Küçük Resim Yok
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Lipid peroksidasyonu (oto oksidasyon) yaşlanma, ateroskleroz, kanser, inflmatuvar hastalıklar, gibi bazı fizyolojik ve patolojik süreçlerde etkin olan doku hasarından sorumlu olan mekanizmalardan biridir. Bu çalışma ile bir antioksidan olan ürik asitin, koroner arter hastalığı açısından bir risk faktörü olup olmadığı ve hastalığın yaygınlığı ile ilişkisi araştırılmıştır. Çalışmaya koroner anjiyografi yapılan, yaş ortalaması 54.7 10.8 yıl olan 720 erkek hasta alındı. Diüretik alan, alkol kullanan, nefropatisi olan ve gut hastalığı tanısı olan hastalar çalışmaya dahil edilmedi. Hastalardan, 12 saatlik açlık sonrası, serum ürik asit ve fibrinojen düzeyleri, çeşitli biyokimyasal parametreler ve lipid parametreleri için kan alındı. 7 mg/dl üzeri serum ürik asit seviyeleri hiperürisemi olarak kabul edildi. Koroner anjiyografi sonucuna göre hastalar iki gruba ayrıldılar; koroner anjiyogramda lezyon saptanan hastalar hasta grubuna dahil edilirken, koroner anjiyogramı normal bulunan hastalar da kontrol grubunu oluşturdular. Hasta grubu tutulum saptanan koroner arter sayısına göre üç alt gruba ayrıldı. Hasta ve kontrol grubu, serum ürik asit, fibrinojen, LDL-kolesterol, total kolesterol seviyeleri, LDL kolesterol / HDL kolesterol oranı, bel-kalça oranı, sigara, diyabet, hipertansiyon, koroner arter hastalığı aile öyküsü açısından karşılaştırıldığı nda, iki grup arasında istatistiksel olarak anlamlı fark olduğu gözlendi (P 0,001). Tek değişkenli analizlerde bu değişkenlerin tamamı koroner arter hastalığı açısından risk faktörü olarak tespit edildiler. Tek değişkenli analizlerde risk faktörü olarak saptanan bu parametreler lojistik regresyon analiziyle değerlendirilerek bağımsız risk faktörü olup olmadıkları araştırıldı. Ürik asit, diabetes mellitus, hipertansiyon, LDL- kolesterolü, koroner arter hastalığı aile öyküsü, fibrinojen, bel kalça oranı bağımsız risk faktörleri olarak bulundu. Ürik asit düzeyi ile etkilenen damar sayısı (yaygınlığı) arasında istatistiksel olarak anlamlı bir ilişki saptanmadı.
Lipid peroxidation is known to be one of the important mechanisms taking role in the development of tissue damage observed in various ongoing physiologic and pathologic processes such as aging, atherosclerosis as well as various inflammatory diseases and cancer. The aim of this study was to analyse any possible relation between uric acid, which is well known to be an antioxidant substance, and coronary artery disease and to also to analyse any possible relation of plasma uric acid levels with the extend of coronary angiografic findings. 720 male patients who underwent coronary angiography for suspected coronary artery disease were included in the study. The mean age was 54.7 ±10.8 years. Patients with known renal disease or gout, patients with alcohol consumption or patients taking diuretics for any reason were excluded from the study. Blood samples were obtained after 12 hours of fasting from each patient on the day of coronary angiography, and analysed for various biochemical parameters including lipid parameters , uric acid and fibrinogen levels. Uric acid levels >7 mg / dl were regarded as hyperuricemia. According to the results of coronary angiography the patients were divided into two groups. The study group was consisted of patients with pathologic coronary angiographic findings whereas patients with normal coronary angiograms were taken into the control group. The study group was also divided into three subgroups according to the number of coronary arteries with angiographic lesions. There was a statistically significant difference between the study and the control groups in terms of serum LDL-cholesterol, total cholesterol, fibrinogen and uric acid levels as well as LDL cholesterol / HDL cholesterol and waist to hip ratio ratios (p <0.001). Also smoking, diabetes mellitus, hypertension, family history were found to be more prevelant in the study than the control group and the differrence was statistically significant as well (p<0.001). Univariate analysis showed that all these parameters are risk factors for coronary artery disease. Logistic regression analysis were performed in order to detect the independent risk factors and serum uric acid, fibrinogen, LDL-cholesterol levels, diabetes mellitus, hypertension, , family history, and waist- hip ratio were found to be independent risk factors. No statistically significant difference was detected between serum uric acid levels and the number of coronary arteries with pathological angiografic findings.
Lipid peroxidation is known to be one of the important mechanisms taking role in the development of tissue damage observed in various ongoing physiologic and pathologic processes such as aging, atherosclerosis as well as various inflammatory diseases and cancer. The aim of this study was to analyse any possible relation between uric acid, which is well known to be an antioxidant substance, and coronary artery disease and to also to analyse any possible relation of plasma uric acid levels with the extend of coronary angiografic findings. 720 male patients who underwent coronary angiography for suspected coronary artery disease were included in the study. The mean age was 54.7 ±10.8 years. Patients with known renal disease or gout, patients with alcohol consumption or patients taking diuretics for any reason were excluded from the study. Blood samples were obtained after 12 hours of fasting from each patient on the day of coronary angiography, and analysed for various biochemical parameters including lipid parameters , uric acid and fibrinogen levels. Uric acid levels >7 mg / dl were regarded as hyperuricemia. According to the results of coronary angiography the patients were divided into two groups. The study group was consisted of patients with pathologic coronary angiographic findings whereas patients with normal coronary angiograms were taken into the control group. The study group was also divided into three subgroups according to the number of coronary arteries with angiographic lesions. There was a statistically significant difference between the study and the control groups in terms of serum LDL-cholesterol, total cholesterol, fibrinogen and uric acid levels as well as LDL cholesterol / HDL cholesterol and waist to hip ratio ratios (p <0.001). Also smoking, diabetes mellitus, hypertension, family history were found to be more prevelant in the study than the control group and the differrence was statistically significant as well (p<0.001). Univariate analysis showed that all these parameters are risk factors for coronary artery disease. Logistic regression analysis were performed in order to detect the independent risk factors and serum uric acid, fibrinogen, LDL-cholesterol levels, diabetes mellitus, hypertension, , family history, and waist- hip ratio were found to be independent risk factors. No statistically significant difference was detected between serum uric acid levels and the number of coronary arteries with pathological angiografic findings.
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp
Kaynak
Haydarpaşa Numune Eğitim ve Araştırma Hastanesi Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
50
Sayı
3
Künye
Gökçe, V., Asıl, M., Avcı, A., Boyacı, A., Korkmaz, Ş., (2010). Ürik Asitin Koroner Arter Hastalığı, Yaygınlığı ve Risk Faktörleri İle İlişkisi. Haydarpaşa Numune Eğitim ve Araştırma Hastanesi Tıp Dergisi, 50(3), 143-150.
