Romatoid Artritli Hastalarda Gözyaşı İncelemesi
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Dosyalar
Tarih
1998
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Romatoid artritin (RA) en sık görülen göz belirtisi keratokonjonktivitis sikkadır (KKS). Çalışmada RA 'lı 38 hastanın 76 gözünde KKS araştırıldı. Araştırmada kullanılan gözyaşı fonksiyon testleri Schirmer-1, gözyaşı parçalanma zamanı (GPZ) ve rose bengal (RB) boyama testlerinden oluşuyordu. Bu testler, laboratuvar koşullarına ihtiyaç duyulmadan kolayca uygulanabilen klinik testlerdir. Çalışmada RA'li hastaların %39.47'sinde KKS tespit edildi. KKS saptanan hastalarda testlerin tanı duyarlılığı araştırıldı. Ayrıca 23 kişilik kontrol grubunun 46 gözünde testlerin tanı duyarlılığı araştırıldı. RA' li hastalar ve kontrol grubu arasında, yaş ve cins dağılımı açısından istatistiksel olarak anlamlı bir fark yoktu (p0.05). GPZ testi %90 ile tanısal duyarlılığı en yüksek test olarak bulunurken, spesifite oranı %76.08 ile diğer iki testten anlamlı olarak daha düşüktü (p0.05). Spesifitesi en yüksek olan text %95.65 ile RB boyama testi idi. Fakat bu testin de tanısal duyarlılığı %66.66 ile diğer iki testten anlamlı olarak daha düşüktü (p0.05). Testlerin kombine olarak kullanılmasıyla yüksek duyarlılık ve spesifite oluşturulmakta ve bu da doğru tanıya gidilmesinde önemli bir etken olmaktadır.
The most common ophthalmological sign of rheumatoid arthritis (RA) is keratoconjunctivitis sicca (KCS). In this study, KCS was investigated in 76 eyes of 38 patients with RA. The tear function tests used were Schirmer-1, tear film break up time and rose bengal (RB) staining tests. These tests can be carried out easily in the outpatient service, without the need of laboratory conditions. In this study, KCS was diagnosed in 39.47 % of the patients with RA and the diagnostic sensitivity of the tests were investigated in KCS. In addition, the diagnostic spesificity ratio of the tests were determined in 46 eyes of 23 subjects in the control group. There was no statistically significant difference between the control group and the patients with RA in terms of age and sex distribution (p>0.05). Tear film break up time test was the most sensitive test with 90% sensitivity, while its specificity (76%) was significantly lower than that of the other two tests (p<0.05). The most spesific test was the RB staining test with a 95.65% of specificity. However, the sensitivity (66.66%) of this test was significantly lower than that of the other two tests (p<0.05). With combined usage of these tests, higher specificity and sensitivity can be obtained which is an important leading factor for accurate diagnosis.
The most common ophthalmological sign of rheumatoid arthritis (RA) is keratoconjunctivitis sicca (KCS). In this study, KCS was investigated in 76 eyes of 38 patients with RA. The tear function tests used were Schirmer-1, tear film break up time and rose bengal (RB) staining tests. These tests can be carried out easily in the outpatient service, without the need of laboratory conditions. In this study, KCS was diagnosed in 39.47 % of the patients with RA and the diagnostic sensitivity of the tests were investigated in KCS. In addition, the diagnostic spesificity ratio of the tests were determined in 46 eyes of 23 subjects in the control group. There was no statistically significant difference between the control group and the patients with RA in terms of age and sex distribution (p>0.05). Tear film break up time test was the most sensitive test with 90% sensitivity, while its specificity (76%) was significantly lower than that of the other two tests (p<0.05). The most spesific test was the RB staining test with a 95.65% of specificity. However, the sensitivity (66.66%) of this test was significantly lower than that of the other two tests (p<0.05). With combined usage of these tests, higher specificity and sensitivity can be obtained which is an important leading factor for accurate diagnosis.
Açıklama
Anahtar Kelimeler
Romatoid artrit, Keratokonjonktivitis sikka, Gözyaşı, Rheumatoid arthritis, Keratoconjunctivitis sicca, Tear film
Kaynak
Türkiye Klinikleri Oftalmoloji Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
7
Sayı
2
Künye
Çelikel, M., Gündüz, K., Okudan, S., Zengin, N., Özkağnıcı, A., (1998). Romatoid Artritli Hastalarda Gözyaşı İncelemesi. Türkiye Klinikleri Oftalmoloji Dergisi, 7(2), 124-127.
