Farklı dozlardaki marbofloksasinin koyunlarda biyokimyasal ve hematolojik parametreler üzerine etkileri
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Dosyalar
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Selçuk Üniversitesi Veterinerlik Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Mevcut araştırmada sağlıklı koyunlarda kas içi farklı dozlarda marbofloksasin uygulamasının biyokimyasal ve hematolojik parametreler üzerine etkisinin belirlenmesi amaçlandı. Gereç ve Yöntem: Çalışma, paralel dizayna göre dört doz grubunda ayrılan 24 adet sağlıklı erkek, 2-5 yaştaki Akkaraman koç üzerinde gerçekleştirildi. Herbir doz grubunda 6 adet hayvan bulunmaktadır. Her gruptaki altı hayvana, semitendinoz kas bölgesinden sırasıyla 2, 4, 6 ve 10 mg/kg tek doz seviyelerinde marbofloksasin enjekte edildi. Kan örnekleri sol vena jugularise yerleştirilen kataterler kullanılarak ilaç uygulanmadan önce (0.saat, kontrol) ve sonraki 10. ve 22. saatlerde alındı. Biyokimyasal parametrelerden albumin, alkalin fosfataz, alanin aminotransferaz, aspartat aminotransferaz, kolesterol, trigliserid, total protein, kan üre nitrojen, kreatinin ve gamma-glutamil transferaz değerleri otoanalizör cihazında belirlendi. Hematolojik parametrelerden beyaz kan hücreleri, kırmızı kan hücreleri, hemoglobin, hematokrit, platelet değerleri kan hücresi sayım cihazında ölçüldü. Bulgular: Gruplar arasında hematolojik ve serum biyokimyasal parametrelerinde anlamlı bir fark bulunamadı. Öneri: Bu sonuçlar koyunlarda tek doz kas içi uygulanmasından sonra 10 mg/kg'a kadar tek bir intramüsküler enjeksiyondan sonra marbofloksasinin hematolojik ve biyokimyasal parametreler üzerinde klinik olarak anlamlı bir etkisinin olmadığını göstermektedir.
Aim: In this study, it was aimed to determine the effect of IM marbofloxacin at different doses on biochemical and hematological parameters in healthy sheep. Materials and Methods: The study was carried out on twenty four healthy Akkaraman rams (2-5 years old) randomly selected in four dose groups according to parallel design. There are six animals in each dose group. There are six animals in each dose group. Six animals in each group were injected with marbofloxacin at the dose levels of 2, 4, 6 and 10 mg/kg, respectively, in the semitendinosus muscle. Blood samples were collected using a catheter placed in the left jugular vein at 0 (pre-treatment), and 10. and 22 hours post-dosing. Biochemical parameters, such as, albumin, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, cholesterol, triglyceride, total protein, blood urea nitrogen, creatinine, and gamma-glutamyl transferase were determined in autoanalyzer. Hematological parameters, such as white blood cells, red blood cells, hemoglobin, hematocrit, and platelet were measured in blood cell counter. Results: No significant differences in hematological and serum biochemical parameters were found between the groups. Conclusion: These results indicate that the marbofloxacin after a single intramuscular injection up to 10 mg/kg following IM administration in sheep had no significant side effects on the biochemical and hematological parameters measured.
Aim: In this study, it was aimed to determine the effect of IM marbofloxacin at different doses on biochemical and hematological parameters in healthy sheep. Materials and Methods: The study was carried out on twenty four healthy Akkaraman rams (2-5 years old) randomly selected in four dose groups according to parallel design. There are six animals in each dose group. There are six animals in each dose group. Six animals in each group were injected with marbofloxacin at the dose levels of 2, 4, 6 and 10 mg/kg, respectively, in the semitendinosus muscle. Blood samples were collected using a catheter placed in the left jugular vein at 0 (pre-treatment), and 10. and 22 hours post-dosing. Biochemical parameters, such as, albumin, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, cholesterol, triglyceride, total protein, blood urea nitrogen, creatinine, and gamma-glutamyl transferase were determined in autoanalyzer. Hematological parameters, such as white blood cells, red blood cells, hemoglobin, hematocrit, and platelet were measured in blood cell counter. Results: No significant differences in hematological and serum biochemical parameters were found between the groups. Conclusion: These results indicate that the marbofloxacin after a single intramuscular injection up to 10 mg/kg following IM administration in sheep had no significant side effects on the biochemical and hematological parameters measured.
Açıklama
Anahtar Kelimeler
Biyokimyasal, hematolojik, koyun, marbofloksasin, yan etki, Biochemical, haematolojical, marbofloxacin, sheep, side effect
Kaynak
Eurasian Journal of Veterinary Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
34
Sayı
2
Künye
Altan, F., Çorum, O., Çorum, D. D., Üney K. (2018).Effects of different doses marbofloxacin on biochemical and
hematological parameters in sheep. Eurasian Journal of Veterinary Sciences, 34 (2), 71-76 DOI: 10.15312/EurasianJVetSci.2018.185
