The effect of 3?,4?-dihydroxyflavonol on plasma oxidant and antioxidant systems in testis ischemia-reperfusion injury in rats

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dc.contributor.authorDuman A.
dc.contributor.authorMogulkoc R.
dc.contributor.authorBaltaci A.K.
dc.contributor.authorSivrikaya A.
dc.date.accessioned2020-03-26T20:11:51Z
dc.date.available2020-03-26T20:11:51Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe purpose of the present study was to determine the effect of 3’,4’-dihydroxyflavonol (DiOHF) on plasma lipid peroxidation in experimental testicular torsion-detorsion.The study involved 60 Wistar-albino type male rats weighing 250-260 gr. The experiment groups were formed as follows: 1. Control; 2. Sham-control; 3.720o-4 hours torsion; 4. 720o-4 hours torsion + 4 hours detorsion; 5. 720o-4 hours torsion + DiOHF; 6. 720o-4 hours torsion + DiOHF + 4 hours detorsion; 7. 720o-4 hours torsion + 24 hours detorsion; 8. 720o-4 hours torsion + DiOHF + 24 hours detorsion. The animals in the experimental groups were anesthetized after the procedures and their blood samples were taken to determine the levels of plasma glutathione peroxidase (GPx), nitric oxide (NO), malondialdehyde (MDA), and erythrocyte glutathione (GSH). Among the study groups, group 5 was found to have the highest plasma glutathione peroxidase values (p<0.001). Groups 3 and 4, which were torsion and detorsion groups, had the lowest plasma GPx values (p<0.001).Plasma NO values were found be higher in groups 3 and 4 than all other groups (p<0.001).Groups 3, 4, and 7 had the highest plasma MDA levels (p<0.001).Erythrocyte GSH levels in groups 5 and 7 were significantly higher than the levels in other groups (p<0.001).The results of the study indicate that lipid peroxidation that increases in plasma during testis ischemia-reperfusion injury in rats is prevented by intra-peritoneal DiOHF administration. © 2018 by the authors.en_US
dc.description.sponsorship10202046en_US
dc.description.sponsorshipThis study was supported by a grant Selcuk University, Scientific Research Council (Grant number is 10202046).en_US
dc.identifier.endpage3445en_US
dc.identifier.issn2069-5837en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage3441en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37242
dc.identifier.volume8en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAMG Transcend Associationen_US
dc.relation.ispartofBiointerface Research in Applied Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subject3?, 4?-dihydroxyflavonolen_US
dc.subjectRaten_US
dc.subjectTestis ischemia-reperfusionen_US
dc.titleThe effect of 3?,4?-dihydroxyflavonol on plasma oxidant and antioxidant systems in testis ischemia-reperfusion injury in ratsen_US
dc.typeArticleen_US

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