Komplike olmayan akut brusellozlu 83 olgunun irdelenmesi
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Tarih
2010
Yazarlar
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Çiriş: Bruselioz, Brucella cinsi bakteriler tarafından oluşturulan, ülkemizde sık görülen sistemik bir zoonozdur. Bruselloz birçok organı etkileyebilme yeteneğine sahip olduğu için farklı klinik tablolarla karşımıza çıkabilir. Komplikasyonları önlemek açısından erken tanı ve tedavi önemlidir. Bu çalışmada, akut brusellozlu 83 olgu prospektif olarak demografik özellikleri, klinik ve laboratuvar bulguları, tedavi protokolleri ve relaps açısından irdelenmiştir. Hastalar ve Metod: Bu çalışma, ileriye dönük olarak Temmuz 2007-Aralık 2008 tarihleri arasında Selçuk Üniversitesi Meram Tıp Fakültesi İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalına akut bruselloz tanısıyla başvuran olgular üzerinde yapılmıştır. Hastaların yaşı, cinsiyeti, beden kitle indeksi, sağlık güvencesi, adres ve telefonları, mesleği, eğitim düzeyleri, bulaş yolları, laboratuvar-kültür sonuçları ve tedavi protokolleri hasta izleme formuna kaydedilmiştir. Bulgular: Çalışmaya alınan 83 bruselloz olgusunun 31 (%37.3)'i erkek, 52 (%62.7)'si kadın olup, genel yaş ortalaması 42.59 (18-77) yıl idi. Olguların %53'ü ev hanımı idi, %80.2'sinde bulaş yolu tespit edildi. En sık bulaş yolu %42 ile süt ve süt ürünlerinin tüketimi olarak saptandı. En sık üç semptom sırasıyla artralji, gece terlemesi ve halsizlik idi. Olguların %26.5'inde anemi, %18.1 'inde trombositopeni, %8.4'ünde lökopeni tespit edildi. Sonuç: Hastalar bir yıl boyunca üç ay aralıklarla izlendi. Klinik şikayetleri tekrarlayan ve infeksiyon parametreleri bruselloza uyan hastalar relaps olarak kabul edildi. Seksen üç hastanın 7 (%8.4)'sinde relaps saptandı. Bu hastaların dördü doksisiklin rifampisin (3/34, %8.8), üçü doksisiklin streptomisin (4/45, %8.8) alan gruptaydı. Relaps yapan ve yapmayan iki grup arasında tedavi etkinliği, yan etki ve relaps açısından fark saptanmadı.
Introduction: Brucellosis is a common disease in our country. Early diagnosis and treatment are important in order to prevent the complications. In this study, 83 patients were evaluated regarding demographic features, clinical and laboratory findings, treatment protocol, and relapses. Patients and Methods: This prospective study was conducted with brucellosis patients admitted to the Clinics of Infectious Diseases and Clinical Microbiology, Selçuk University, Meram Faculty of Medicine between July 2007 and December 2008. Age, gender, body mass index, social and health insurance, address and telephone number, occupation, level of education, route of transmission, laboratory culture results, and treatment protocols of the patients were recorded in the patient evaluation form. Results: Of the 83 brucellosis cases included in the study, 31 (37.3%) were male, 52 (62.7%) were female and the average age was 42.59 (range: 18-77). Fifty three percent of the cases were housewives. Route of transmission was established in 80.2%, and the most common route of transmission (42%) was consumption of dairy products. The three most frequent complaints were arthralgia, night sweating and fatigue. Anemia was detected in 26.5% of the patients, thrombocytopenia in 18.1% and leukopenia in 8.4%. C-reactive protein (CRP) elevation was detected in 55 and erythrocyte sedimentation rate (ESR) elevation in 47 patients. Conclusion: Patients were followed up at three-month intervals. Patients with recurrent clinical symptoms and infectious parameters resembling brucellosis were considered as relapse cases. Relapse was detected in 7 of 83 patients (8.4%). Four (3/34, 8.8%) of these cases were in the doxycycline rifampicin group and 3 (4/45, 8.8%) were in the doxycycline streptomycin group. There was no difference between the doxycycline rifampicin and doxycycline streptomycin treatment groups with respect to treatment efficacy, side effects and relapses.
Introduction: Brucellosis is a common disease in our country. Early diagnosis and treatment are important in order to prevent the complications. In this study, 83 patients were evaluated regarding demographic features, clinical and laboratory findings, treatment protocol, and relapses. Patients and Methods: This prospective study was conducted with brucellosis patients admitted to the Clinics of Infectious Diseases and Clinical Microbiology, Selçuk University, Meram Faculty of Medicine between July 2007 and December 2008. Age, gender, body mass index, social and health insurance, address and telephone number, occupation, level of education, route of transmission, laboratory culture results, and treatment protocols of the patients were recorded in the patient evaluation form. Results: Of the 83 brucellosis cases included in the study, 31 (37.3%) were male, 52 (62.7%) were female and the average age was 42.59 (range: 18-77). Fifty three percent of the cases were housewives. Route of transmission was established in 80.2%, and the most common route of transmission (42%) was consumption of dairy products. The three most frequent complaints were arthralgia, night sweating and fatigue. Anemia was detected in 26.5% of the patients, thrombocytopenia in 18.1% and leukopenia in 8.4%. C-reactive protein (CRP) elevation was detected in 55 and erythrocyte sedimentation rate (ESR) elevation in 47 patients. Conclusion: Patients were followed up at three-month intervals. Patients with recurrent clinical symptoms and infectious parameters resembling brucellosis were considered as relapse cases. Relapse was detected in 7 of 83 patients (8.4%). Four (3/34, 8.8%) of these cases were in the doxycycline rifampicin group and 3 (4/45, 8.8%) were in the doxycycline streptomycin group. There was no difference between the doxycycline rifampicin and doxycycline streptomycin treatment groups with respect to treatment efficacy, side effects and relapses.
Açıklama
Anahtar Kelimeler
Bruselloz, Prospektif çalışmalar, Brucellosis, Prospective studies
Kaynak
Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
15
Sayı
3
Künye
Demir, N. A., Ural, O. (2010). Komplike Olmayan Akut Brusellozlu 83 Olgunun İrdelenmesi. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, 15(3), 123-128.
