Meningiomlardaki Kromozomal Anomaliler
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Dosyalar
Tarih
2001
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Çalışmanın amacı, meningiomlarda rastlanan karyotipik anomalileri tanımlamak, tümörlerin histopatolojik özellikleri ve yerleşim yerleri ile birlikte değerlendirmektir. Sitogenetik analizler 28 olguluk çalışma grubundan kurulan hücre kültürlerinden elde edilen metafazların GTG-bandlama yöntemiyle gerçekleştirildi ve değerlendirmeler ISCN 1995'e uygun olarak yapıldı. Elde edilen verilere göre, kromozomal anomalisi olmayan olgu sayısı 10(%36), sadece monozomi 22'li olgu sayısı 8 (%28.6), monozomi 22'ye ek olarak 1., 4., 8., 10., 12., 15., 17., 19., ve 20. kromozomlarla, X ve Y kromozomlarına ait anomalilere sahip olgu sayısı 10 (%36) idi. Toplam kromozomal anomalili olgu sayısı 18(%64) olarak saptandı.Olguların ikisinde kompleks translokasyonlar, birinde klonal olarak değerlendirilemeyen çeşitli yapısal kromozomal anomaliler izlendi. Diğer olgularda çeşitli otozomal kromozomlara ve cinsiyet kromozomlarına ait kayıplar mevcuttu. Histopatolojik tiplemede meningotelyal olan olguların altısında, fibroblastik olan olguların üçünde, transisyonel olan olguların dördünde, psammamatöz, angioblastik ve anaplastik olan olguların ise tümünde karyotipik anomali mevcuttu. Kromozom anomalileri ve tümörün yerleşim yeri arasındaki ilişki gözden geçirildiğinde, karyotipik anomali saptanan 18 olgudan 12'sinde tümör'ün beyin konveksitesine yerleştiği görüldü. Sonuçlarımıza göre, meningiomlarda kromozom 22'nin sık kayba uğramasının yanında, çeşitli diğer klonal karyotipik anomaliler ortaya çıkmakta, biyolojik ve patolojik bulguların çeşitliliğine yol açmaktadır.
The aim of this study was to identify the most frequent karyotypic abnormalities in meningiomas associated with histopathology and anatomic sites of tumor origin. Cytogenetic analysis of 28 cultured human meningiomas were performed by GTG-banding and evaluated according to ISCN 1995. It was revealed that 10(% 36) had normal karyotype, 8 (% 28.6) had monosomy 22 which was the sole abnormality and 10 (% 36) had structural abnormalities or loss of chromosomesl,4, 8,10, 12, 15, 17, 19, 20, X and Y in addition to monosomy 22. Various chromosomal abnormalities were found in 18 (%64) of these cases. Two cases exhibited complex translocations, in one patient various types of structural and numerical but non-clonal chromosomal abnormalities were found. Numerical alterations involving autosomal and sex, chromosomes were detected in others. Karyotypic abnormalities were detected in six of meningothelial and three of fibroblastic and four of transtional, and all of psammomatous, angioblastic and anaplastic meningiomas. Correlation between tumors locations and their karyotypes were evaluated and it was seen that 12 of 18 cases whose tumors were located on the brain convexity had chromosomal abnormalities. Our results illustrated that, in addition to the frequent loss of chromosome 22, numerous other clonal karyotypic abnormalities exist in meningiomas, reflecting the heterogenity of biological and pathological findings.
The aim of this study was to identify the most frequent karyotypic abnormalities in meningiomas associated with histopathology and anatomic sites of tumor origin. Cytogenetic analysis of 28 cultured human meningiomas were performed by GTG-banding and evaluated according to ISCN 1995. It was revealed that 10(% 36) had normal karyotype, 8 (% 28.6) had monosomy 22 which was the sole abnormality and 10 (% 36) had structural abnormalities or loss of chromosomesl,4, 8,10, 12, 15, 17, 19, 20, X and Y in addition to monosomy 22. Various chromosomal abnormalities were found in 18 (%64) of these cases. Two cases exhibited complex translocations, in one patient various types of structural and numerical but non-clonal chromosomal abnormalities were found. Numerical alterations involving autosomal and sex, chromosomes were detected in others. Karyotypic abnormalities were detected in six of meningothelial and three of fibroblastic and four of transtional, and all of psammomatous, angioblastic and anaplastic meningiomas. Correlation between tumors locations and their karyotypes were evaluated and it was seen that 12 of 18 cases whose tumors were located on the brain convexity had chromosomal abnormalities. Our results illustrated that, in addition to the frequent loss of chromosome 22, numerous other clonal karyotypic abnormalities exist in meningiomas, reflecting the heterogenity of biological and pathological findings.
Açıklama
Anahtar Kelimeler
Kromozomal Anomali, Meningiom, Monozomi 22, Sitogenetik, Chromosomal Abnormalies, Cytogenetics, Meningioma, Monosomy 22
Kaynak
Türk Nöroşirürji Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
11
Sayı
1
Künye
Zamani, A. G., Durakbaşı, H. G., Acar, A., Acar, O., Özkal, E., (2001). Meningiomlardaki Kromozomal Anomaliler. Türk Nöroşirürji Dergisi, 11(1), 15-22.
