Farklı dozlardaki marbofloksasinin koyunlarda biyokimyasal ve hematolojik parametreler üzerine etkileri
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Mevcut araştırmada sağlıklı koyunlarda kas içi farklıdozlarda marbofloksasin uygulamasının biyokimyasal ve hematolojikparametreler üzerine etkisinin belirlenmesi amaçlandı.Gereç ve Yöntem: Çalışma, paralel dizayna göre dört doz grubundaayrılan 24 adet sağlıklı erkek, 2-5 yaştaki Akkaramankoç üzerinde gerçekleştirildi. Herbir doz grubunda 6 adet hayvanbulunmaktadır. Her gruptaki altı hayvana, semitendinoz kasbölgesinden sırasıyla 2, 4, 6 ve 10 mg/kg tek doz seviyelerindemarbofloksasin enjekte edildi. Kan örnekleri sol vena jugulariseyerleştirilen kataterler kullanılarak ilaç uygulanmadan önce(0.saat, kontrol) ve sonraki 10. ve 22. saatlerde alındı. Biyokimyasalparametrelerden albumin, alkalin fosfataz, alanin aminotransferaz,aspartat aminotransferaz, kolesterol, trigliserid, totalprotein, kan üre nitrojen, kreatinin ve gamma-glutamil transferazdeğerleri otoanalizör cihazında belirlendi. Hematolojikparametrelerden beyaz kan hücreleri, kırmızı kan hücreleri,hemoglobin, hematokrit, platelet değerleri kan hücresi sayımcihazında ölçüldü.Bulgular: Gruplar arasında hematolojik ve serum biyokimyasalparametrelerinde anlamlı bir fark bulunamadı.Öneri: Bu sonuçlar koyunlarda tek doz kas içi uygulanmasındansonra 10 mg/kg'a kadar tek bir intramüsküler enjeksiyondansonra marbofloksasinin hematolojik ve biyokimyasal parametrelerüzerinde klinik olarak anlamlı bir etkisinin olmadığınıgöstermektedir.
Aim: In this study, it was aimed to determine the effect of IMmarbofloxacin at different doses on biochemical and hematologicalparameters in healthy sheep.Materials and Methods: The study was carried out on twentyfour healthy Akkaraman rams (2-5 years old) randomly selectedin four dose groups according to parallel design. There are sixanimals in each dose group. There are six animals in each dosegroup. Six animals in each group were injected with marbofloxacinat the dose levels of 2, 4, 6 and 10 mg/kg, respectively, inthe semitendinosus muscle. Blood samples were collected usinga catheter placed in the left jugular vein at 0 (pre-treatment),and 10. and 22 hours post-dosing. Biochemical parameters,such as, albumin, alkaline phosphatase, alanine aminotransferase,aspartate aminotransferase, cholesterol, triglyceride, totalprotein, blood urea nitrogen, creatinine, and gamma-glutamyltransferase were determined in autoanalyzer. Hematologicalparameters, such as white blood cells, red blood cells, hemoglobin,hematocrit, and platelet were measured in blood cell counter.Results: No significant differences in hematological and serumbiochemical parameters were found between the groups.Conclusion: These results indicate that the marbofloxacin aftera single intramuscular injection up to 10 mg/kg following IMadministration in sheep had no significant side effects on thebiochemical and hematological parameters measured.
Aim: In this study, it was aimed to determine the effect of IMmarbofloxacin at different doses on biochemical and hematologicalparameters in healthy sheep.Materials and Methods: The study was carried out on twentyfour healthy Akkaraman rams (2-5 years old) randomly selectedin four dose groups according to parallel design. There are sixanimals in each dose group. There are six animals in each dosegroup. Six animals in each group were injected with marbofloxacinat the dose levels of 2, 4, 6 and 10 mg/kg, respectively, inthe semitendinosus muscle. Blood samples were collected usinga catheter placed in the left jugular vein at 0 (pre-treatment),and 10. and 22 hours post-dosing. Biochemical parameters,such as, albumin, alkaline phosphatase, alanine aminotransferase,aspartate aminotransferase, cholesterol, triglyceride, totalprotein, blood urea nitrogen, creatinine, and gamma-glutamyltransferase were determined in autoanalyzer. Hematologicalparameters, such as white blood cells, red blood cells, hemoglobin,hematocrit, and platelet were measured in blood cell counter.Results: No significant differences in hematological and serumbiochemical parameters were found between the groups.Conclusion: These results indicate that the marbofloxacin aftera single intramuscular injection up to 10 mg/kg following IMadministration in sheep had no significant side effects on thebiochemical and hematological parameters measured.
Açıklama
Anahtar Kelimeler
Veterinerlik
Kaynak
Eurasian Journal of Veterinary Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
34
Sayı
2
