Serum Prohepcidin and Hepcidin Levels in Patients withAnkylosing Spondylitis: A Prospective Study
Küçük Resim Yok
Tarih
2016
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Anemi, Ankilozan spondilit (AS) gibi enflamatuar hastalıklarda sık görülen bir komplikasyondur. Son veriler hepsidinin demir homeostaz ve metabolizmasında rol aldığını ve aneminin önemli bir aracısı olduğunu göstermektedir. Bu çalışmanın amacı, AS'li hastalarda ve sağlıklı kontrollerde serum hepsidin ve hepsidinin prohormonu olan prohepsidin düzeylerinin değerlendirilmesidir. Gereç ve Yöntem: Bu çalışmaya, AS'li kırk hasta (13 anemi olan ve 27 anemi olmayan) ile 20 sağlıklı katılımcı prospektif olarak alındı. Tam kan sayımı, eritrosit sedimantasyon hızı, serum hepsidin, prohepsidin, demir, total demir bağlama kapasitesi, ferritin, transferrin, ve C-reaktif protein düzeyleri ölçüldü. Bulgular: Serum prohepsidin ve hepsidin düzeyleri sağlıklı kontrol ile karşılaştırıldığında, AS'li hastalarda anlamlı olarak yüksek (p 0.005) bulundu. AS'li hastalarda, serum hepsidin ve prohepsidin düzeyleri arasında pozitif korelasyon ( 0.725 r, p 0.001) arasında saptandı. Tartışma: Bizim bilgilerimize göre bu çalışma AS'li hastalarda serum prohepsidin ve hepsidin düzeylerinin araştırıldığı ilk çalışmadır. AS'li hastalarda serum prohepsidin ve hepsidin düzeylerinin hastalığın aktivitesi ile yakından ilişkili olabileceği ve AS ile kronik hastalık anemisinin patogenezinde rol oynayabileceği düşünülmektedir.
Aim: Anemia is a common complication in patients with inflammatory diseases such as ankylosing spondylitis. Recent data suggest that hepcidin is a major mediator of anemia with a central role in iron homeostasis and metabolism. The aim of this study was to evaluate the serum levels of hepcidin and its prohormone, prohepcidin, in patients with ankylosing spondylitis in comparison with healthy controls. Material and Method: Forty patients with ankylosing spondylitis (13 with anemia and 27 without anemia), 20 healthy adults were prospectively enrolled. Complete blood count, erythrocyte sedimentation rate, serum levels of hepcidin, prohepcidin, iron, total iron binding capacity, ferritin, transferrin, and C-reactive protein were measured. Results: Serum levels of prohepcidin and hepcidin were significantly higher in patients with ankylosing spondylitis compared to healthy controls (p<0.005). Positive correlation was determined between the serum hepcidin and prohepcidin levels in patients with ankylosing spondylitis (r0.725, p<0.001). Discussion: To the best of our knowledge, this is the first report of serum levels of prohepcidin and hepcidin in the patients with ankylosing spondylitis. Serum levels of prohepcidin and hepcidin are closely associated with disease activity in patients with ankylosing spondylitis and might play a role in the pathogenesis of anemia of chronic disease associated with ankylosing spondylitis.
Aim: Anemia is a common complication in patients with inflammatory diseases such as ankylosing spondylitis. Recent data suggest that hepcidin is a major mediator of anemia with a central role in iron homeostasis and metabolism. The aim of this study was to evaluate the serum levels of hepcidin and its prohormone, prohepcidin, in patients with ankylosing spondylitis in comparison with healthy controls. Material and Method: Forty patients with ankylosing spondylitis (13 with anemia and 27 without anemia), 20 healthy adults were prospectively enrolled. Complete blood count, erythrocyte sedimentation rate, serum levels of hepcidin, prohepcidin, iron, total iron binding capacity, ferritin, transferrin, and C-reactive protein were measured. Results: Serum levels of prohepcidin and hepcidin were significantly higher in patients with ankylosing spondylitis compared to healthy controls (p<0.005). Positive correlation was determined between the serum hepcidin and prohepcidin levels in patients with ankylosing spondylitis (r0.725, p<0.001). Discussion: To the best of our knowledge, this is the first report of serum levels of prohepcidin and hepcidin in the patients with ankylosing spondylitis. Serum levels of prohepcidin and hepcidin are closely associated with disease activity in patients with ankylosing spondylitis and might play a role in the pathogenesis of anemia of chronic disease associated with ankylosing spondylitis.
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp
Kaynak
Journal of Clinical and Analytical Medicine
WoS Q Değeri
Scopus Q Değeri
Cilt
7
Sayı
1
