Evaluation of smoking genotoxicity in Turkish young adults

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dc.contributor.authorZamani, A. G.
dc.contributor.authorDurakbaşı, Hatice Gül Dursun
dc.contributor.authorDemirel, S.
dc.contributor.authorAcar, A.
dc.date.accessioned2020-03-26T18:22:14Z
dc.date.available2020-03-26T18:22:14Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBACKGROUND: For the past few decades, it has been widely known in developed countries that tobacco is dangerous, but it is still insufficiently realized how big these dangers really are. AIMS: To determine and evaluate micronuclei (MN) frequencies of young smokers and nonsmokers in three different tissues (peripheric blood lymphoctes, buccal mucosa, and exfoliative urothelial cells) at the same time. MATERIALS AND METHODS: MN assay was performed on buccal mucosa, urothelial cells, and peripheric blood lymphocyte samples obtained from 15 healthy male smokers (>5 pack-years) and 15 healthy male nonsmoker controls who had not been exposed to any known genotoxic agent. STATISTICAL ANALYSIS USED: The statistical differences between smoker and nonsmoker groups were calculated by using student t test. The differences between smoker-group tissues were compared by ANOVA. RESULTS: It was found that MN frequency (mean value standard deviation) in oral mucosa cells from smokers and controls were 1.20 ± 0.22% and 0.26 ± 0.10%; in urothelial exfoliative cells, 1.29 ± 0.28% and 0.12 ± 0.08%; in peripheric blood lymphocytes, 1.53 ± 0.23% and 0.38 ± 0.12%, respectively. The mean MN frequencies in buccal mucosa, urothelial exfoliative cells, and peripheric blood lymphocytes were significantly higher in smokers than in those of controls (P<0.05). All tissues were affected from smoking, but the most destructive effect was seen in urothelial cells of smokers (P<0.05). CONCLUSIONS: Our data showed that cigarette smoke is a DNA damage causitive agent on exfoliative buccal mucosa and urothelial cells and peripheric blood lymphocytes of young smokers, but it has most destructive effect on urothelial cells.en_US
dc.identifier.doi10.4103/0971-6866.82186en_US
dc.identifier.endpage12en_US
dc.identifier.issn0971-6866en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage7en_US
dc.identifier.urihttps://dx.doi.org/10.4103/0971-6866.82186
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27229
dc.identifier.volume17en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofIndian Journal of Human Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBuccal mucosaen_US
dc.subjectGenotoxicityen_US
dc.subjectHuman lymphocytesen_US
dc.subjectMicronucleusen_US
dc.subjectUrothelial cellen_US
dc.titleEvaluation of smoking genotoxicity in Turkish young adultsen_US
dc.typeArticleen_US

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