Comparison of the effects of an adhesion barrier and chitin on experimental epidural fibrosis [Deneysel epidural fibroziste adezyon bariyeri ile chitin'in etkinli?inin karşlaştırılması]

Basit Öğe Kaydı
dc.contributor.authorKeskin F.
dc.contributor.authorEsen H.
dc.date.accessioned2020-03-26T18:05:39Z
dc.date.available2020-03-26T18:05:39Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim: Epidural fibrosis is an important factor for postoperative failed back syndrome development and causes clinical complaints in 6-25% of cases. An effective treatment modality has not been found yet. The aim of this study is to investigate the anti-adhesive effects of a novel agent chitin and compare these effects with a popular adhesion barrier collagen matrix. Mat erial and Methods: 21 rabbits were allocated into three groups including 7 rabbits each. L5 total laminectomy was performed to all groups. No treatment was given to Group 1 (Control group). Collagen matrix was used in Group 2 and chitin was used in Group 3. Six weeks later all rabbits were sacrificed and the laminectomy areas were entirely resected and investigated histopathologically. Results: He and Revel grade III epidural fibrosis was detected in the control group. Statistically significant reduction of epidural fibrosis was achieved with both of the anti-adhesive agents, collagen matrix and chitin, when compared with the control group (p<0.05). The results were not different between treatment groups (p>0.05). Conclusion: The novel agent chitin was found effective for preventing epidural fibrosis and this effect was not significantly different from the collagen matrix. In light of our findings we suggest that chitin is an effective alternative for adhesion barriers.en_US
dc.identifier.doi10.5137/1019-5149.JTN.3205-10.2en_US
dc.identifier.endpage463en_US
dc.identifier.issn1019-5149en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage457en_US
dc.identifier.urihttps://dx.doi.org/10.5137/1019-5149.JTN.3205-10.2
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25495
dc.identifier.volume20en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherTurkish Neurosurgical Societyen_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAdhesion barriersen_US
dc.subjectChitinen_US
dc.subjectEpidural fibrosisen_US
dc.titleComparison of the effects of an adhesion barrier and chitin on experimental epidural fibrosis [Deneysel epidural fibroziste adezyon bariyeri ile chitin'in etkinli?inin karşlaştırılması]en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Tıbbi Pataloji/Makale Koleksiyonu