Spinal Anestezi ile Sezaryen Operasyonlarında Profilaktik Ondansetron ve Metoklopramidin Antiemetik Etkinliklerinin Araştırılması
Küçük Resim Yok
Tarih
2004
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Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Amaç: Spinal anestezi altında sezaryen operasyonu geçiren olgularda bulantı ve kusmanın profilaktik tedavisinde ondansentron ve metoklopramidin etkinliği araştırıldı. Gereç ve Yöntem: ASA I-II grubunda sezaryen operasyonu gerektiren 60 gebe rastgele 3 gruptan birine alındı (n20) ve çift-kür, plasebo kontrollü protokol uygulandı. Umbilikal kord klamplendikten sonra, 8 mgr ondansentron (grup I), 10 mgr metoklopramidin (grup II) ve %0.9 saline (grup III) intravenöz olarak verildi. Bulantı ve kusma epizodları, ek antiemetik gereksinimi ve yan etkileri kaydedildi. Bulgular: İntraoperatif bulantı insidansı Grup I, II ve III'te sırası ile %20.3, %46 ve %60 idi (p0.05). İntraoperatif kusma insidansı Grup I, II ve III'te sırası ile %6, %33 ve %53 olarak bulundu (p0.05). Postoperatif 24 saatlik dönemde kusma insidansı %6, %33 ve %53 iken (p 0.05) postoperatif 24 saatte bulantı insidansı Grup I ve II'de benzer fakat Grup III' te anlamlı derecede yüksekti (p0.05). Ek antiemetik gereksinimi Grup I'de Grup II ve III'e göre anlamlı derecede düşüktü (p 0.05). Yan etkileri bakımından gruplar arasında fark yoktu. Sonuç: Spinal anestezi altındaki sezaryen operasyonlarında intravenöz 8 mgr verilen profilaktik ondansentron intraoperatif bulantı ve kusma, postoperatif bulantının önlenmesinde 10 mgr intravenöz metoklopramidin veya plasebodan çok daha etkili bulundu. Bununla birlikte postoperatif kusmanın frekansında ondansentron ile metoklopramidin arasında fark bulunmadı.
Objective: The efficacy of ondansentron and metoclopramide were evaluated for prophylactic treatment of nausea and vomiting in cesarean section patients under spinal anaesthesia. Materials and Methods: Sixty ASA physical status I-II parturients requiring cesarean section gave this consent and were randomly assigned into one of three treatments groups (n20) according to a double-blind, placebo-controlled protocol. After umblical cord clamping, ondansentron 8 mgr (Group I), metoclopramide 10 mgr (Group II), 0.9% saline (Group III) were injected intravenously. Episodes of nausea and vomiting, resque antiemetic requirement and side effects were recorded. Results: The frequency of intraoperative nausea were 20.3%, 46% and 60% for group I, II and III respectively (p<0.05). The frequency of intraoperative vomiting 6%, 33%, 53% for group I, II and III respectively (p<0.05). The frequency of postoperative 24 hour period nausea were 23%, 48%, 69% for group I, II and III respectively (p<0.05) and vomiting were similiar between group I and II but significantly higher in group III (p<0.05). Resque antiemetic requirement were lower in group I than group II and group III (p<0.05). Side effects were not significantly amoung groups. Conclusion: In cesarean section under spinal anaesthesia, prophylactic ondansentron 8 mgr intravenously is more efficacious than metoclopramide 10 mgr intravenously or placebo in preventing nausea during first 24 hour postoperative period. However, there is no difference between ondansentron and metoclopramide in reducing frequency of vomiting postoperative period.
Objective: The efficacy of ondansentron and metoclopramide were evaluated for prophylactic treatment of nausea and vomiting in cesarean section patients under spinal anaesthesia. Materials and Methods: Sixty ASA physical status I-II parturients requiring cesarean section gave this consent and were randomly assigned into one of three treatments groups (n20) according to a double-blind, placebo-controlled protocol. After umblical cord clamping, ondansentron 8 mgr (Group I), metoclopramide 10 mgr (Group II), 0.9% saline (Group III) were injected intravenously. Episodes of nausea and vomiting, resque antiemetic requirement and side effects were recorded. Results: The frequency of intraoperative nausea were 20.3%, 46% and 60% for group I, II and III respectively (p<0.05). The frequency of intraoperative vomiting 6%, 33%, 53% for group I, II and III respectively (p<0.05). The frequency of postoperative 24 hour period nausea were 23%, 48%, 69% for group I, II and III respectively (p<0.05) and vomiting were similiar between group I and II but significantly higher in group III (p<0.05). Resque antiemetic requirement were lower in group I than group II and group III (p<0.05). Side effects were not significantly amoung groups. Conclusion: In cesarean section under spinal anaesthesia, prophylactic ondansentron 8 mgr intravenously is more efficacious than metoclopramide 10 mgr intravenously or placebo in preventing nausea during first 24 hour postoperative period. However, there is no difference between ondansentron and metoclopramide in reducing frequency of vomiting postoperative period.
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp
Kaynak
Medical Network Klinik Bilimler ve Doktor
WoS Q Değeri
Scopus Q Değeri
Cilt
10
Sayı
3
Künye
Çelik, J. B., Reisli, R., Gezginç, K., Tuncer, S., Ökesli, S., Akyürek, C., (2004). Spinal Anestezi ile Sezaryen Operasyonlarında Profilaktik Ondansetron ve Metoklopramidin Antiemetik Etkinliklerinin Araştırılması. Medical Network Klinik Bilimler ve Doktor, 10(3), 343-347.
