Hiperbilirubinemili Yenidoğanlarda Fototerapinin Serbest Radikaller Üzerine Etkisi
Küçük Resim Yok
Tarih
1999
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: İndirekt hiperbilirubinemili yenidoğanlarda fototerapinin serbest radikallere etkisinin araştırılması amaçlandı. Yöntem: Total bilirubinleri 15 mg/dl'nin üzerinde olan ve ortalama 44 saat fototerapi uygulanan 25 bebekte (fototerapi grubu) fototerapi öncesi ve sonrası bilirubin, hematokrit ve reaktif oksijen metabolitleri (ROM) düzeyi ölçüldü. Fototerapi uygulanmayan ve total bilirubin seviyeleri 10-15 mg/dl olan 25 bebek de (kontrol grubu) takibe alındı. Bulgular: Bebeklerin gebelik yaşları, ağırlıkları ve numune alındığı zamanki yaşam süreleri bakımından iki grup arasında önemli fark yoktu. Total bilirubin, direkt bilirubin, hematokrit ve ROM değerleri sırasıyla; fototerapi grubunda fototerapi öncesi 16.6 1.2 mg/dl, 0.5 0.1 mg/dl, % 56.8 4.8, 322 81 car unit. Fototerapi sonrası 8.1 1.5 mg/dl, 0.4 0.2 mg/dl, % 53.9 5.4, 240 64 car unit, kontrol grubunda ise 1. numunede 11.6 2.6 mg/dl, 0.4 0.1 mg/dl, % 55.0 4.8, 307 92 car unit, 2. numunede 11.8 1.9 mg/dl, 0.4 0.1 mg/dl, % 51.5 4.8, 314 80 car unit idi. Bilirubin değerleri yüksek olan ve fototerapi uygulanan grubun bilirubin ve ROM değerleri fototerapi sonrasında fototerapi öncesine göre anlamlı olarak düşüktü. Kontrol grubunda ise ilk ve ikinci ölçümler arasında fark yoktu. Sonuç: Fototerapi ile bilirubin değerleri düşerken ROM değerlerinde azalma olmaktadır.
Objective: It was aimed to evaluate the effects of phototherapy on free oxygen radicals in newborns with indirect hyperbilirubinemia. Methods: Determination of bilirubin, hematocrit and reactive oxygen metabolites (ROM) levels were carried out before and after phototeraphy in 25 newborns (phototheraphy group) in whom total bilirubin was higher than 15 mg/dl. 25 newborn in whom total bilirubin was 10-15 mg/dl constituted the control group. Results: There was no statistical difference between gestational age, weight and life-span of the infants. The values of total bilirubin, direct bilirubin, hematocrit and reactive oxygen metabolites (ROMs) were 16.6± 1.2 mg/dl, 0.5± 0.1 mg/dl, 56.8± 4.8%, 322± 81 car unit before and 8.1± 1.5 mg/dl, 0.4± 0.2 mg/dl, 53.9± 5.4%, 240± 64 car unit after phototherapy in the phototherapy group, respectively. The values were 11.6± 2.6 mg/dl, 0.4± 0.1 mg/dl, 55.0± 4.8%, 307± 92 car unit and 11.8± 1.9 mg/dl, 0.4± 0.1 mg/dl, 51.5± 4.8 %, 314± 80 car unit in the control group at the first and the second samples, respectively. The levels of total bilirubin and ROMs before phototherapy were higher than those after phototherapy in the patient group. There was no statistical differences between values of hematocrit before and after phototherapy. Conclusion: We conclude that phototherapy decreases the levels of bilirubin as well as ROMs.
Objective: It was aimed to evaluate the effects of phototherapy on free oxygen radicals in newborns with indirect hyperbilirubinemia. Methods: Determination of bilirubin, hematocrit and reactive oxygen metabolites (ROM) levels were carried out before and after phototeraphy in 25 newborns (phototheraphy group) in whom total bilirubin was higher than 15 mg/dl. 25 newborn in whom total bilirubin was 10-15 mg/dl constituted the control group. Results: There was no statistical difference between gestational age, weight and life-span of the infants. The values of total bilirubin, direct bilirubin, hematocrit and reactive oxygen metabolites (ROMs) were 16.6± 1.2 mg/dl, 0.5± 0.1 mg/dl, 56.8± 4.8%, 322± 81 car unit before and 8.1± 1.5 mg/dl, 0.4± 0.2 mg/dl, 53.9± 5.4%, 240± 64 car unit after phototherapy in the phototherapy group, respectively. The values were 11.6± 2.6 mg/dl, 0.4± 0.1 mg/dl, 55.0± 4.8%, 307± 92 car unit and 11.8± 1.9 mg/dl, 0.4± 0.1 mg/dl, 51.5± 4.8 %, 314± 80 car unit in the control group at the first and the second samples, respectively. The levels of total bilirubin and ROMs before phototherapy were higher than those after phototherapy in the patient group. There was no statistical differences between values of hematocrit before and after phototherapy. Conclusion: We conclude that phototherapy decreases the levels of bilirubin as well as ROMs.
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp
Kaynak
Genel Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
9
Sayı
3
Künye
Koç, H., Aköz, M., Gürbilek, M., Ak, M., Ay, M., Gürel, A., Çalışkan, Ü., (1999). Hiperbilirubinemili Yenidoğanlarda Fototerapinin Serbest Radikaller Üzerine Etkisi. Genel Tıp Dergisi, 9(3), 87-91.
