Controlled trial of efficacy of dexketoprofen in sciatic nerve crush injury in rats [Si{dotless}çanlarda siyatik sinir yaralanmasi{dotless}nda deksketoprofenin etkinli?inin kontrollü çali{dotless}şmasi{dotless}]

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dc.contributor.authorKaptan H.
dc.contributor.authorKasimcan O.
dc.contributor.authorAyaz M.
dc.contributor.authorBozdogan O.
dc.contributor.authorKarabagli H.
dc.date.accessioned2020-03-26T18:58:50Z
dc.date.available2020-03-26T18:58:50Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObject: Local applications of Dexketoprofen trometamol (dex) have been shown to increase in the sciatic nerve functional tests following the nerve injuries. The aim of the current study was to compare the efficacy of dex application for 1 and 5 days following nerve injury rat model. Possible effects of dex were checked by means of the Sciatic Function Index (SFI), Withdrawal of the Reflex Leg (WRL), number of axons, axon diameter, and nerve diameters. Material Methods: The animal crushed model was done through Aesculap -Yasargil aneurysm method on Wistar albino (N=21) right sciatic nerves. In order to achieve desired purpose 3 experimental groups were organized: Group 1: control (injured and no drug); Group2: dexketoprofen 1 days (injured and single dose of drug); Group3: dexketoprofen 5 days (injured and single dose of 5 times drug applications). Injections were done through the tissue expander's injection port with a connecting tube directed at the crush-injured site. Functional recovery of the sciatic nerves was evaluated with the improvement in the SFI values. Additionally, recovery of sensory function was assessed through WRL results and histopathological examination was performed 6 week following the injury. Results: At the end of the experimental periods there was no significant differences were found between the experimental group of animals on the bases of the number of axons, axon diameter, and nerve diameter. Moreover, up 30th day of the experimental period our functional test results have shown that there was no difference between the groups. But following the induction of the injury, the statistical significances were seen on the functional tests. This effect was seen only if the multi-dose application of the dex. Conclusions: This study suggests that; dexketoprofen trometamol of 5 consecutive days, has revealed positive significant changes in the sciatic nerve injury through analgesic effect of it.en_US
dc.identifier.endpage135en_US
dc.identifier.issn1300-1817en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage126en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31304
dc.identifier.volume31en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherEge University Pressen_US
dc.relation.ispartofJournal of Neurological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAxon number and nerve diameteren_US
dc.subjectClippingen_US
dc.subjectDexketoprofen trometamolen_US
dc.subjectFiber diameteren_US
dc.subjectNerve injuryen_US
dc.titleControlled trial of efficacy of dexketoprofen in sciatic nerve crush injury in rats [Si{dotless}çanlarda siyatik sinir yaralanmasi{dotless}nda deksketoprofenin etkinli?inin kontrollü çali{dotless}şmasi{dotless}]en_US
dc.typeArticleen_US

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