Antiviral activity of Spartium junceum against herpes simplex virus type 1: An in-vitro study

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dc.contributor.authorDuman, Rüstem.
dc.contributor.authorDoğan, Hasan Hüseyin.
dc.contributor.authorKarakış, Hilal.
dc.date.accessioned2020-03-26T20:12:33Z
dc.date.available2020-03-26T20:12:33Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractThis study was carried out to evaluate the antiviral activities of methanol and aqueous extracts prepared from the flowers and stems of Spartium junceum L., used as herbal medicine in the treatment of gastric ulcer in Turkish folk medicine, against herpes simplex virus type 1 (HSV-1). The maximum non-toxic concentration of the extracts (MNTC) was determined against Vero cells by using the serial two-fold dilution of MNTC (specific for each extract). The cytotoxic activity of the extracts and their ability to inhibit the cytopathic effect (CPE) caused by the virus in tissue culture was evaluated by colorimetric XTT assay after three days of inoculation and incubation. 50% cytotoxic concentration (CC50) and 50% effective concentration (EC50) were determined using graph pad prism, and the selectivity index (SI) was calculated from the EC50 ratio of CC50. As a result of the research, the strongest antiviral activity against HSV-1 was determined from flower aqueous extract with 1290.88 mu g/mL EC50 and 24.09 SI values, and this was followed by stem aqueous extract (EC50 = 1217.52 mu g/mL, SI = 12.22), flower methanol (EC50 = 1673.41 mu g/mL, SI = 6.74) and stem methanol extracts (EC50 = 795.31 mu g/mL, SI = 4.86). As a result, we can say that S. junceum extracts are worthy of further study to develop as an alternative to the drugs used clinically against HSV-1. This is the first report on S. junceum for anti-HSV-1 activity.en_US
dc.description.sponsorshipSelcuk University, Scientific Research Projects Coordinating OfficeSelcuk University [SU-BAP-18401048]en_US
dc.description.sponsorshipThe authors would like to thank Selcuk University, Scientific Research Projects Coordinating Office (SU-BAP-18401048) for the project funding.en_US
dc.identifier.citationDuman, R., Doğan, H. H., Karakış, H. (2019). Antiviral Activity of Spartium junceum Against Herpes Simplex Virus Type 1: An in-Vitro Study. International Journal of Pharmaceutical Sciences and Research, 10(7), 3274-3282.
dc.identifier.doi10.13040/IJPSR.0975-8232.10(7).3274-82en_US
dc.identifier.endpage3282en_US
dc.identifier.issn0975-8232en_US
dc.identifier.issue7en_US
dc.identifier.pmid#YOKen_US
dc.identifier.startpage3274en_US
dc.identifier.urihttps://dx.doi.org/10.13040/IJPSR.0975-8232.10(7).3274-82
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37487
dc.identifier.volume10en_US
dc.identifier.wosWOS:000473298000016en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorDuman, Rüstem.
dc.institutionauthorDoğan, Hasan Hüseyin.
dc.institutionauthorKarakış, Hilal.
dc.language.isoenen_US
dc.publisherINT JOURNAL PHARMACEUTICAL SCIENCES & RESEARCHen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAnti HSV-1 activityen_US
dc.subjectCytotoxic concentrationen_US
dc.subjectCytopathic effecten_US
dc.subjectSpartium junceumen_US
dc.titleAntiviral activity of Spartium junceum against herpes simplex virus type 1: An in-vitro studyen_US
dc.typeArticleen_US

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