Erken membran rüptürü ve erken doğum tehditi olan gebelerde Listeria monocytogenes insidansı
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Date
2004
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Abstract
AMAÇ: Erken membran rüptürü ve erken doğum tehditi olan gebelerde listeria monocytogenezin insidansının araştırılması. MATERYAL ve METOD: 28-37. gebelik haftaları arasındaki 43 erken doğum tehditi, 34 erken membran rüptürü olmak üzere çalışma grubunu oluşturan 77 gebe ve 40 sağlıklı gebe olmak üzere toplam 117 gebe çalışmaya alındı. Listeria monocytogenesin insidansı araştırılırken kültür ve serolojik testlerden yararlanıldı. BULGULAR: Erken doğum tehditi olan bir gebede L. Monocytogenes, erken membran rüptürü olan bir gebede ise L. İnnocua olmak üzere çalışma grubunda toplam iki hastada (% 2,5) kültürde listeriozis saptandı. Kültür sonucuna göre gruplar arasında istatiksel farklılık saptanmadı. Çalışma grubunda, Listeria aglütinasyon tip 4bH, 4bO, IO ve IH antijenlerine karşı 1/160 ve üzeri pozitiflik yalnızca tip 4bO ve IO olmak üzere toplam sekiz hastada (% 10.3) saptandı. Fakat, bu vakalarda listeria kültürlerinde üreme olmadı. Hastalardan biri erken doğum tehditi olan gebeyken, diğer yedisinin erken membran rüptürü vardı. Kontrol grubunda 1/160 ve üzerinde bu dört tip antijene karşı antikor pozitifliği saptanmadı. Antikor pozitifliği bakımından çalışma grubu ile kontrol grubu arasında istatistiki farklılık saptandı (P0.05). SONUÇ: Listeryozis prenatal mortalitenin önlenebilir nadir nedenlerinden biridir. Preterm eylemde ve erken membran rüptürü olan gebelerde ve konjenital enfeksi-yonlarda L. Monocytogenes nadir de olsa etyolojik bir faktör olarak düşünülebilir ve saptandığında ise tedavisine erken dönemde başlanılması uygun olacaktır.
OBJECTIVE: To investigate the incidence of Listeria monocytogenes infection in pregnant women with premature rupture of membranes and preterm labor. STUDY DESIGN: We chose 77 pregnant women who were between 28th to 37th weeks of gestation as the study group. Within this group, 34 patients had premature rupture of membranes and 43 had preterm labor. Forty healthy pregnant women were served as the control group to a total of 117 women to participate in the study. To detect Listeria monocytogenes infection, we used bacterial cultures and serological tests. RESULT(s): Listeria monocytogenes was diagnosed in a patient with premature labor and Listeria innocua was found in a patient with premature rupture of membranes. In total, listeriosis was detected in 2 (2.5%) patients in the study group, not statistically significant in comparison to the control group. Listeria agglutination type 4bH, 4bO, IO and IH serotypes were examined in the study group. An antibody titer of 1/160 or above was accepted as positive. In 8 patients (10.3%), positive antibody titers were detected for type 4bO and type IO, but their cultures were negative for Listeria. One out of 8 patients has premature labor, and the other 7 patients had premature rupture of membranes. An antibody titer of 1/160 or above against these four serotypes was not detected in the control group. The difference between the study and the control groups was significant in terms of antibody titers of 1/160 or above (p<0.05). CONCLUSION: Listeriosis is a rare preventable cause of prenatal mortality. Maternal listeriosis may causes premature birth, premature rupture of membranes and congenital infection of the newborn. In pregnant women with premature labor or premature rupture of membranes, Listeria monocytogenes should be thought as one possible etiologic factor and the infection should be treated if diagnosis is established.
OBJECTIVE: To investigate the incidence of Listeria monocytogenes infection in pregnant women with premature rupture of membranes and preterm labor. STUDY DESIGN: We chose 77 pregnant women who were between 28th to 37th weeks of gestation as the study group. Within this group, 34 patients had premature rupture of membranes and 43 had preterm labor. Forty healthy pregnant women were served as the control group to a total of 117 women to participate in the study. To detect Listeria monocytogenes infection, we used bacterial cultures and serological tests. RESULT(s): Listeria monocytogenes was diagnosed in a patient with premature labor and Listeria innocua was found in a patient with premature rupture of membranes. In total, listeriosis was detected in 2 (2.5%) patients in the study group, not statistically significant in comparison to the control group. Listeria agglutination type 4bH, 4bO, IO and IH serotypes were examined in the study group. An antibody titer of 1/160 or above was accepted as positive. In 8 patients (10.3%), positive antibody titers were detected for type 4bO and type IO, but their cultures were negative for Listeria. One out of 8 patients has premature labor, and the other 7 patients had premature rupture of membranes. An antibody titer of 1/160 or above against these four serotypes was not detected in the control group. The difference between the study and the control groups was significant in terms of antibody titers of 1/160 or above (p<0.05). CONCLUSION: Listeriosis is a rare preventable cause of prenatal mortality. Maternal listeriosis may causes premature birth, premature rupture of membranes and congenital infection of the newborn. In pregnant women with premature labor or premature rupture of membranes, Listeria monocytogenes should be thought as one possible etiologic factor and the infection should be treated if diagnosis is established.
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Kadın Hastalıkları ve Doğum
Journal or Series
Jinekoloji ve Obstetrik Derg.
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Volume
18
Issue
2
