Evaluation of adrenal function in chronic obstructive pulmonary disease patients receiving invasive and noninvasive mechanical ventilation

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dc.contributor.authorAtalay H.
dc.contributor.authorTeke T.
dc.contributor.authorYavuz Z.
dc.contributor.authorMaden E.
dc.contributor.authorKiyici A.
dc.contributor.authorSolak Y.
dc.contributor.authorUzun K.
dc.date.accessioned2020-03-26T18:05:41Z
dc.date.available2020-03-26T18:05:41Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractStress and severe disease states in the intensive care unit (ICU) cause release of adrenocorticoid hormone from the hypophysis and cortisol from the adrenal cortex by activating hypothalamo-pituitary adrenal axis. While adrenal insuffi ciency (AI) is seen in less than 0.01% of the normal population, its frequency is over 28% of cases in intensive care units (ICU). The aim of this study was to evaluate adrenal function in 36 cases with COPD, in pulmonary diseases ICU, receiving invasive mechanical ventilation (IMV) (n:23) and noninvasive mechanical ventilation (NIMV) (n:13). For this purpose, after obtaining a blood sample for baseline cortisol level, 1mg ACTH was given to patients in the fi rst day of admission to ICU. Cortisol levels were checked at the 30th and 60th minutes of ACTH test. Of all cases, mean age was 67.3±9.2, duration of hospitalization 12.9±9.3 days, APACHE II score 20.9±5.4, systolic blood pressure (bp) 103.5±28.2 mmHg, diastolic bp 64.6±19.2, mean arterial blood pressure 81.5±20.5 mmHg, sodium 138.3 ±6.3, potassium 4.3±1.2, urea 83.8±62.5 and creatinine was1.38±0.9 respectively. According to baseline cortisol levels, AI was present in 22 (45%) patients. Of these cases, 11 were in NIMV and 11 in IMV groups. When the baseline, 30th minute and 60th minute cortisol levels were compared, a statistically signifi cant difference was present (p<0.05, for all). In conclusion, we consider that adrenal insuffi ciency is encountered frequently in COPD patients with respiratory failure and further studies are needed tobetter delineate this association.en_US
dc.identifier.citationAtalay, H., Teke, T., Yavuz, Z., Maden, E., Kıyıcı, Y., Uzun, K. (2010). Evaluation of Adrenal Function in Chronic Obstructive Pulmonary Disease Patients Receiving İnvasive and Noninvasive Mechanical Ventilation. Journal of Medical and Surgical Intensive Care Medicine, 1(1), 6-9.
dc.identifier.endpage9en_US
dc.identifier.issn1309-1689en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage6en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25506
dc.identifier.volume1en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorAtalay H.
dc.institutionauthorTeke T.
dc.institutionauthorYavuz Z.
dc.institutionauthorMaden E.
dc.institutionauthorKiyici A.
dc.institutionauthorSolak Y.
dc.institutionauthorUzun K.
dc.language.isotren_US
dc.publisherAVESen_US
dc.relation.ispartofJournal of Medical and Surgical Intensive Care Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAdrenal insuffi ciencyen_US
dc.subjectCOPDen_US
dc.subjectMechanical ventilationen_US
dc.subjectSteroiden_US
dc.titleEvaluation of adrenal function in chronic obstructive pulmonary disease patients receiving invasive and noninvasive mechanical ventilationen_US
dc.typeArticleen_US

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