The Effect of Dehydroepiandrosterone Sulfate on Oxidant Status, Copper and Zinc Levels in Hind Leg Muscle of the Rats Fed with High-Fat Diet

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dc.contributor.authorAri, Zeki
dc.contributor.authorUlman, Cevval
dc.contributor.authorTaneli, Fatma
dc.contributor.authorIsbilen, Banu
dc.contributor.authorUyanik, B. Sami
dc.contributor.authorAldirmaz, Huri
dc.contributor.authorCelik, H. Tugrul
dc.date.accessioned2020-03-26T17:28:02Z
dc.date.available2020-03-26T17:28:02Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObesity can be induced by a high fat diet. Dehydroepiandrosterone sulfate decreases body fat mass and have an antiatherogenic effect. The objective of our study was to investigate the high fat diet changes and the effect of dehydroepiandrosterone sulfate on the antioxidant status, zinc and copper levels in the rat hind leg muscle tissue. Thirty-seven female rats were divided into 4 groups. Group 1 ( control, n=11) were fed with standard rat chow, Group 2, 3 and 4 with high fat diet (65%) for five months. Dehydroepiandrosterone sulfate was administered as 1 mg/kg for group 3 (n=9) and as 10 mg/kg for group 4 (n=8) daily for seven days. The same amount of saline was injected to group 1 and 2 (n=9). After decapitation, right hind leg of the rat was collected and kept frozen. Muscle tissues were used for the determination of nitrotyrosine, myeloperoxidase activity, copper and zinc levels. As a conclusion, dehydroepiandrosterone sulfate significantly decreases the oxidant status parameters, tissue nitrotyrosine levels and myeloperoxiase activity in the rat hind leg muscle tissue on high fat diet, but did not have any effect on copper and zinc tissue levels. We believe that, further research is needed for investigation of the positive effects of DHEA-S on muscle metabolism.en_US
dc.identifier.endpage8en_US
dc.identifier.issn0250-4685en_US
dc.identifier.issn1303-829Xen_US
dc.identifier.issue1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22699
dc.identifier.volume33en_US
dc.identifier.wosWOS:000260581000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherWALTER DE GRUYTER GMBHen_US
dc.relation.ispartofTURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectHigh lipid dieten_US
dc.subjectdehydroepiandrosterone sulfateen_US
dc.subjectnitrotyrosineen_US
dc.subjectmyeloperoxidaseen_US
dc.subjecttrace elementsen_US
dc.titleThe Effect of Dehydroepiandrosterone Sulfate on Oxidant Status, Copper and Zinc Levels in Hind Leg Muscle of the Rats Fed with High-Fat Dieten_US
dc.typeArticleen_US

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