Genel anestezi ve genel anestezi ile birlikte uygulanan epidural levobupivakain veya bupivakain anestezisinin karşılaştırılması
Küçük Resim Yok
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Cerrahi travmaya karşı oluşacak stres yanıtın baskılanması, intraoperatif hemodinami ve postoperatif analjezi kalitesi yönünden; genel anesteziye eklenen epidural bupivakain veya levobupivakain anestezisi ile genel anesteziyi karşılaştırılmayı amaçladık. Gereç ve Yöntem: Çalışmaya total abdominal histerektomi bilateral salpingoooferektomi (TAH-BSO) planlanan 54 vaka kabul edildi. Olgular genel anesteziepidural bupivakain (Grup I), genel anesteziepidural levobupivakain (Grup II) ve genel anestezi (Grup III) uygulanan grup şeklinde randomize olarak 3 gruba ayrıldı. Monitorizasyon sonrası Grup I ve Grup II’ye lomber epidural kateter yerleştirilerek, duyusal blok seviyesi T6 dermatomuna ulaştığında 2 mg kg-1 propofol, 1 µ kg-1 dk-1 remifentanil, 0.6 mg kg-1 rokuronyum ile genel anestezi uygulandı. Grup III’e de monitorizasyon sonrası aynı şekilde indüksiyon sağlandı. Anestezi idamesi tüm gruplarda % 50 O2-% 50 hava karışımı içinde %1 sevofluran ve 0.1 µg kg-1 dk-1 remifentanil infüzyonu ile sağlandı. Glukoz, kortizol, insülin, C reaktif protein (CRP) analizi için preoperatif, postoperatif 1. ve 24. saatlerde kan örnekleri alındı. Olgular; hemodinami, duyusal ve motor blok seviyeleri, kullanılan anestezik miktarları, anesteziden derlenme, postoperatif ağrı ve yan etkiler açısından takip edildi. Postoperatif ağrı tedavisi için; Grup I’e epidural bupivakainmorfin, Grup II’ye epidural levobupivakain morfin ile hazırlanan hasta kontrollü analjezi (HKA), Grup III’e iv morfin HKA uygulandı. Bulgular: Grup I ve II arasında duyusal bloğun T6 dermatomuna ulaşma zamanı, duyusal blok üst seviyesi ve motor blok açısından farklılık tespit edilmedi (p0.05). Perioperatif kullanılan remifentanil ve sevofluran toplam dozları ve ilave kas gevşetici gereksinimi Grup III’te, Grup I ve II’ye göre anlamlı olarak daha yüksekti (p0.05). Spontan solunum zamanı, ekstübasyon zamanı, göz açma zamanı, Aldrete derlenme skoru 9 olma zamanı Grup III’te, Grup I ve II’ye göre anlamlı olarak uzun idi (p0.05). Gruplar arasında glukoz, insülin ve CRP değerleri bakımından tüm zamanlarda anlamlı farklılık görülmedi (p0.05). Kortizol değeri, postoperatif 1. saatte Grup III’te, Grup I ve II’ye göre anlamlı olarak daha yüksek idi (p0.05). Visual analog skala (VAS) değeri 0. dk.’da Grup III’te en yüksek idi, diğer ölçüm zamanlarında anlamlı bir farklılık tespit edilmedi. Bulantı-kusma ve kaşıntı, Grup III’te daha fazla gözlenmesine rağmen, gruplar arasında anlamlı fark yok idi (p0.05). Sonuç: Epidural bupivakain veya levobupivakainin etkileri açısından benzer olduğu, epidural genel anestezinin, genel anesteziye kıyasla intraoperatif olarak daha iyi hemodinamik stabilite sağladığı, özellikle postoperatif ilk saatlerde daha iyi analjezi sağladığı ve stres yanıtı daha iyi baskılayabildiği kanaatine varıldı.
Aim: In this study, we aimed to compare the effects of general anesthesia and general anesthesia combined with epidural anesthesia, using two different local anesthesics levobupivacane or bupivakaine on the response to surgical stress, intraoperative hemodynamics, recovery, advers effects and postoperative analgesia. Materials and Methods: Fiftyfour patients scheduled for TAH-BSO were randomly divided into three groups,. General anesthesiaepidural bupivacaine group (Group I), general anesthesiaepidural levobupivacaine group (Group II) and general anesthesia group (Group III) were assigned. Lomber epidural catheter was placed in Group I and Group II. Anesthesia was induced in Group I and Group II, after T6 sensorial block were achieved. Anaesthesia induction was performed with propofol 2 mg kg-1, remifentanil 1 µ kg-1 min-1 and rocuronium 0.6 mg kg-1, in all groups. Anaesthesia maintanence was provided with in 50 % O2-air, 1 % sevoflurane and 0.1 µg kg-1 min-1 remifentanil infusion. Blood glucose, cortisol, insulin and CRP were measured. Preoperatively and postoperative 1st and 24th hours. All patients assessed in terms of hemodynamic values, the levels of sensorial and motor block, total dose of sevoflurane and remifentanil used intraoperatively, recovery, VAS and side effects. Epidural bupivacainemorphine patient controlled analgesia (PCA) was used in Group I, epidural levobupivacainemorphine PCA was used in Group II and iv morphine PCA was used in Group III, for postoperative pain management. Results: There were no significant diffirences between Group I and Group II in terms of time to reach to T6 dermatome, maximum sensorial block level, and motor block (p>0.05). Total remifentanil, sevoflurane and neuromusculer blocker requirements were greater in Group III compared to other two groups (p<0.05). Spontane respiration time, extubation time, eye opening time, &#8805;9 Aldrete Recovery Score time to were statistically longer in Group III than Group I and Group II (p<0.05). Glucose, insulin and CRP values were similar at all times, among the groups (p>0.05). Cortisol values increased at 1st hour postoperatively in Group III than Group I and Group II (p<0.05). VAS values were greatest at the 0. minutes in Group III, but there were no diffirence at other times. In terms of postoperative side effects, nause-vomiting and pruritis were more frequent in Group III, but these were not statistically significant (p>0.05). Conclusion: According to these results, we concluded that epidural bupivacaine&#8217;s and levobupivacaine&#8217;s effects were similar in our study and we also concluded that epidural anaesthesia combined with general anaesthesia; provide better hemodynamic stability and analgesia postoperatively, suppressed stres response compared to general anaesthesia.
Aim: In this study, we aimed to compare the effects of general anesthesia and general anesthesia combined with epidural anesthesia, using two different local anesthesics levobupivacane or bupivakaine on the response to surgical stress, intraoperative hemodynamics, recovery, advers effects and postoperative analgesia. Materials and Methods: Fiftyfour patients scheduled for TAH-BSO were randomly divided into three groups,. General anesthesiaepidural bupivacaine group (Group I), general anesthesiaepidural levobupivacaine group (Group II) and general anesthesia group (Group III) were assigned. Lomber epidural catheter was placed in Group I and Group II. Anesthesia was induced in Group I and Group II, after T6 sensorial block were achieved. Anaesthesia induction was performed with propofol 2 mg kg-1, remifentanil 1 µ kg-1 min-1 and rocuronium 0.6 mg kg-1, in all groups. Anaesthesia maintanence was provided with in 50 % O2-air, 1 % sevoflurane and 0.1 µg kg-1 min-1 remifentanil infusion. Blood glucose, cortisol, insulin and CRP were measured. Preoperatively and postoperative 1st and 24th hours. All patients assessed in terms of hemodynamic values, the levels of sensorial and motor block, total dose of sevoflurane and remifentanil used intraoperatively, recovery, VAS and side effects. Epidural bupivacainemorphine patient controlled analgesia (PCA) was used in Group I, epidural levobupivacainemorphine PCA was used in Group II and iv morphine PCA was used in Group III, for postoperative pain management. Results: There were no significant diffirences between Group I and Group II in terms of time to reach to T6 dermatome, maximum sensorial block level, and motor block (p>0.05). Total remifentanil, sevoflurane and neuromusculer blocker requirements were greater in Group III compared to other two groups (p<0.05). Spontane respiration time, extubation time, eye opening time, &#8805;9 Aldrete Recovery Score time to were statistically longer in Group III than Group I and Group II (p<0.05). Glucose, insulin and CRP values were similar at all times, among the groups (p>0.05). Cortisol values increased at 1st hour postoperatively in Group III than Group I and Group II (p<0.05). VAS values were greatest at the 0. minutes in Group III, but there were no diffirence at other times. In terms of postoperative side effects, nause-vomiting and pruritis were more frequent in Group III, but these were not statistically significant (p>0.05). Conclusion: According to these results, we concluded that epidural bupivacaine&#8217;s and levobupivacaine&#8217;s effects were similar in our study and we also concluded that epidural anaesthesia combined with general anaesthesia; provide better hemodynamic stability and analgesia postoperatively, suppressed stres response compared to general anaesthesia.
Açıklama
Anahtar Kelimeler
Cerrahi
Kaynak
Türk Anestezi ve Reanimasyon Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
36
Sayı
2
