Dosimetric comparison of two different whole brain radiotherapy techniques in patients with brain metastases: How to decrease lens dose?

dc.contributor.authorYavas, G.
dc.contributor.authorYavas, C.
dc.contributor.authorGul, O. V.
dc.contributor.authorAcar, H.
dc.contributor.authorAta, O.
dc.date.accessioned2020-03-26T18:50:09Z
dc.date.available2020-03-26T18:50:09Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Palliative whole brain radiotherapy (WBRT) has been the standard treatment for brain metastases. Ionizing radiation is known to be one of the most potent cataractogenic agents. We aimed to evaluate two different radiotherapy techniques with respect to the doses received by the organs at risk (OAR) in patients with brain metastasis who undergone WBRT. Materials and Methods: Ten consecutive patients with brain metastasis were included. For each patient, two different treatment plans were created for whole brain. Helmet-field (HF) (anterior border was 2 cm posterior to lens, inferior border was the bottom of C2 vertebra) and classical technique with collimation (CT) (anterior border was defined as skin fall off, inferior border was the bottom of cranial base) were generated for all patients. Two techniques were compared with respect to the doses received by the OAR including bilateral lenses, optic nerves and eye-balls, the dose homogeneity index (DHI), and the monitor unit counts (MU) required for the treatment. Student-t test was used for statistical analysis. Results: There was no difference between two techniques in terms of both DHI (p: 0.182) and MU counts (p: 0.167). The maximum and mean doses received by the right lens, left lens and right eye-ball were significantly reduced with CT (p values for maximum doses 0.007, 0.012 and 0.010; for median doses 0.027, 0.046 and 0.002 respectively). Conclusion: CT was found to be more advantageous, with respect to the lens doses in addition the dose received by the right eye-ball during WBRT.en_US
dc.identifier.endpage317en_US
dc.identifier.issn2322-3243en_US
dc.identifier.issue4en_US
dc.identifier.startpage311en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30756
dc.identifier.volume12en_US
dc.identifier.wosWOS:000348584000004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherIJRR-IRANIAN JOURNAL RADIATION RESen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF RADIATION RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBrain metastasisen_US
dc.subjectwhole brain radiotherapyen_US
dc.subjectlens doseen_US
dc.subjectcataracten_US
dc.titleDosimetric comparison of two different whole brain radiotherapy techniques in patients with brain metastases: How to decrease lens dose?en_US
dc.typeArticleen_US

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