Cerebellar cortical abiotrophy in a Samoyed dog
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Dosyalar
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Selçuk Üniversitesi Veterinerlik Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Serebellar abiotrofi birçok hayvan türünde cinsiyetten ba- ğımsız, otozomal, kalıtsal nitelikte tipik olarak Purkinje hücrelerinin progresif kaybıyla karakterize bir durumdur. Mevcut vakada travma veya başka hastalık hikayesi olmayan ataksi gözlenen bir haftalık Samoyed ırkı bulunmaktadır. Fiziksel muayenede kontrolsüz hareketler, gövdede ılımlı ataksi ve başta şiddetli titremeler gözlendi. Ayrıca köpek yerken sıkıntılı, otururken ve yürürken düşmeden sıkıntılı gözlendi. Hastada tam kan, serebrospinal sıvı analizi ve serebral radiyografi normal gözlendi. Tedavide uygulanan diazepam, vitamin B1 ile glukokortikoidler klinik belirtiler üzerine etkili olmadı ve bir ay sonra köpek öldü. Klinik ve histopatolojik belirtilere göre serebellar kortikal abiotrofi olgusu tanımlandı. Mevcut vaka Samoyed ırkı köpekte tanımlanan ilk serebellar kortikal abiotrofi özelliğinin taşımaktadır.
Cerebellar abiotrophies have a non-sex-linked, autosomal, recessively inherited basis in anumber of animal species, and lesions typically reflect progressive loss of Purkinje cells. In this report, ataxia was observed in a one-week-old male Samoyed puppy with no history of trauma or any other illness. Physical examination revealed uncoordinated movements, mild trunkal ataxia and intensive head tremors, so the dog had trouble eating, evacuating and difficulties in standing and walking without falling. The complete cell count, cerebrospinal fluid analysis and cerebral radiographs were normal. Treatment with diazepam, vitamin B1 and glucocorticoids had no effect on clinical signs and the dog died after a month. According to clinical signs and histopathological features, cerebellar cortical abiotrophy was diagnosed. This is the first report of a cerebellar cortical abiotrophy in a Samoyed puppy
Cerebellar abiotrophies have a non-sex-linked, autosomal, recessively inherited basis in anumber of animal species, and lesions typically reflect progressive loss of Purkinje cells. In this report, ataxia was observed in a one-week-old male Samoyed puppy with no history of trauma or any other illness. Physical examination revealed uncoordinated movements, mild trunkal ataxia and intensive head tremors, so the dog had trouble eating, evacuating and difficulties in standing and walking without falling. The complete cell count, cerebrospinal fluid analysis and cerebral radiographs were normal. Treatment with diazepam, vitamin B1 and glucocorticoids had no effect on clinical signs and the dog died after a month. According to clinical signs and histopathological features, cerebellar cortical abiotrophy was diagnosed. This is the first report of a cerebellar cortical abiotrophy in a Samoyed puppy
Açıklama
Anahtar Kelimeler
Samoyed, serebellar abiotrofi, granular hücreler, Purkinje hücreleri, cerebellar abiotrophy, granular cells, Purkinje cells
Kaynak
Eurasian Journal of Veterinary Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
30
Sayı
1
Künye
Saberi, M., Kheirandish, R., Azizi, S., Mohebbi, E., (2012). Cerebellar cortical abiotrophy in a Samoyed dog. Eurasian Journal of Veterinary Sciences, 30 (1), 44-47.
