Hepatit B Virus Enfeksiyonu ve Glutatyon
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Dosyalar
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Selçuk Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmada, hepatit B virus enfeksiyonlu olgularda, karaciğer enflamasyonunu, hastalık progresyonunu takip etmede ve karaciğer hasarının ilerleyip, kronik karaciğer hastalığı ve komplikasyonların oluşmasını önlemede tedavi için kullanılabilecek antioksidan glutatyonun serum düzeylerine bakıldı. Gereç ve Yöntem: Çalışmaya hepatit B virus enfeksiyonlu, ALT düzeyleri normal, HBV DNA Neg-<104 c/ml, 18-69 yaş arası 55 olgu ile sağlıklı, herhangi bir kronik hastalığı ve akut hepatit olmayan 40 kontrol grubu alındı. Serum GSH düzeyleri, ELISA (Enzyme-Linked Immunosorbent Assay) yöntemi (R&D Systems, Minneapolis, MN, USA) ile belirlendi. Bulgular: Hepatit B virus enfeksiyonlu olguların 29’u kadın, 26’sı erkek (yaş aralığı 43.75±4.33), kontrol grubunun 17’si kadın, 23’ü erkek (yaş aralığı 29.31±1.59) idi. hepatit B virüs enfeksiyonlu olgular arasında serum GSH düzeyi ile yaş ve cinsiyet arasında istatistiksel olarak anlamlı bir farklılık saptanmadı (sırasıyla p: 0.252, p: 0.353). Hepatit B virus enfeksiyonunda glutatyon serum düzeyleri kontrol grubundan düşük olup bu istatiksel açıdan anlamlıydı (sırasyla 117.47±3.12, 151.18±1.93 ng/ mL, p:0.001). Hepatit B enfeksiyonunda, biyokimyasal parametreler ve glutatyon arasında istatiksel olarak anlamlı bir fark saptanmadı ( p>0.05). Sonuç: Oksidatif stres, karaciğer hasarının gelişimi ve ilerlemesinde önemlidir. Glutatyon, hepatit B enfeksiyonlu olgularda, karaciğer enflamasyonunu, hastalık progresyonunu takip etmede kullanılabilir. Ayrıca, antioksidan etkisiyle enflamasyonu baskılayarak, kronik karaciğer hastalığı ve komplikasyonların oluşumunu önlemek için tedavide kullanılabilir.
Objective: In this study, serum levels of antioxidant glutathione which can be used to follow of liver inflammation and disease progression and in treatment to prevent progressive liver damage and chronic liver disease and complications in patients with hepatitis B virus infection, were evaluated. Material and Methods: The study included 55 patients with hepatitis B virus infection, normal ALT levels, HBV DNA Neg- <104 c / ml, between the ages of 18-69 and 40 healthy controls, without any chronic disease or acute hepatitis. Serum GSH levels were determined by ELISA (Enzyme-Linked Immunosorbent Assay) method (R&D Systems, Minneapolis, MN, USA). Results: Of the hepatitis B virus infected cases, 29 were female and 26 were male (age range 43.75 ± 4.33), 17 of the control group were female and 23 were male (age range 29.31 ± 1.59). No statistically significant difference was found between the serum GSH level and age and gender among the cases with hepatitis B virus infection (p: 0.252, p: 0.353, respectively). Glutathione serum levels in hepatitis B virus infection were lower than control group and this was statistically significant (117.47±3.12, 151.18±1.93 ng/mL, respectively, p:0.001). There was no statistically significant difference between biochemical parameters and glutathione in patients with hepatitis B virus infection (p> 0.05). Conculusion: Oxidative stress is important in the development and progression of liver damage Glutathione can be used in patients with hepatitis B infection, to follow liver inflammation and disease progression. In addition, it can be used in treatment to prevent the occurrence of chronic liver disease and complications by suppressing inflammation with its antioxidant effect.
Objective: In this study, serum levels of antioxidant glutathione which can be used to follow of liver inflammation and disease progression and in treatment to prevent progressive liver damage and chronic liver disease and complications in patients with hepatitis B virus infection, were evaluated. Material and Methods: The study included 55 patients with hepatitis B virus infection, normal ALT levels, HBV DNA Neg- <104 c / ml, between the ages of 18-69 and 40 healthy controls, without any chronic disease or acute hepatitis. Serum GSH levels were determined by ELISA (Enzyme-Linked Immunosorbent Assay) method (R&D Systems, Minneapolis, MN, USA). Results: Of the hepatitis B virus infected cases, 29 were female and 26 were male (age range 43.75 ± 4.33), 17 of the control group were female and 23 were male (age range 29.31 ± 1.59). No statistically significant difference was found between the serum GSH level and age and gender among the cases with hepatitis B virus infection (p: 0.252, p: 0.353, respectively). Glutathione serum levels in hepatitis B virus infection were lower than control group and this was statistically significant (117.47±3.12, 151.18±1.93 ng/mL, respectively, p:0.001). There was no statistically significant difference between biochemical parameters and glutathione in patients with hepatitis B virus infection (p> 0.05). Conculusion: Oxidative stress is important in the development and progression of liver damage Glutathione can be used in patients with hepatitis B infection, to follow liver inflammation and disease progression. In addition, it can be used in treatment to prevent the occurrence of chronic liver disease and complications by suppressing inflammation with its antioxidant effect.
Açıklama
Anahtar Kelimeler
Hepatit B virus enfeksiyonu, glutatyon, oksidatif stres, Hepatitis B virus infection, glutathione, oxidative stress
Kaynak
Selçuk Genel Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
31
Sayı
3
Künye
Şenol, A., (2021). Hepatit B Virus Enfeksiyonu ve Glutatyon. Selçuk Genel Tıp Dergisi, 31 (3), 239-242.
