Kan kültürlerinden izole edilen Pseudomonas aeruginosa suşlarının antibiyotiklere direnç oranları
Küçük Resim Yok
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Pseudomonas aeruginosa ciddi hastane infeksiyonlarına yol açabilen ve yaygın olarak kullanılan birçok antibiyotiğe karşı dirençli önemli bir patojendir. Bu çalışmanın amacı, hastanemizde yatan hastaların kan kültürlerinden izole edilen P.aeruginosa izolatlarının çeşitli antibiyotiklere direncinin belirlenmesidir. Çalışmada 2008-2009 yıllarında kan kültürlerinden izole edilen 92 P.aeruginosa suşunun antibiyotiklere direnci retrospektif olarak incelenmiştir. Bakteri identifikasyonu konvansiyonel yöntemler ve Phoenix 100 BD Otomatize Sistemi (Becton Dickinson Diagnostic Systems, Sparks) kullanılarak yapılmıştır. Bakterilerin antibiyotiklere duyarlılıkları, Clinical Laboratory Standards Institute (CLSI) önerileri dikkate alınarak Kirby-Bauer disk difüzyon yöntemi ile, kolistin duyarlılığı ise otomatize sistem (Phoenix Becton Dickinson ID) ile belirlenmiştir. Direnç oranları amikasine ve piperasilin/tazobaktama % 18, piperasiline % 25, siprofloksasine % 28, imipeneme % 30, seftazidime % 32, gentamisine % 35, sefepime % 41 ve sefotaksime % 91 olarak saptanmıştır. Kolistine direnç tespit edilmemiştir. Kolistin, amikasin ve piperasilin/tazobaktamın diğer antibiyotiklere göre daha etkili olduğu belirlenmiştir.
Pseudomonas aeruginosa is an important nosocomial pathogen which causes serious hospital infections and is resistant to many commonly used antibiotics. This study aims to determine the antibiotic resistance of P.aeruginosa strains isolated from bloodstream infections in our hospital. Antibiotic resistance of P.aeruginosa strains isolated from blood cultures in 2008-2009 years were assessed retrospec-tively. The isolates were identified by conventional methods and Phoenix 100 BD automated system (Becton Dickinson Diagnostic Systems, Sparks). Antibiotic susceptibility test was performed by Kirby-Bauer disk-diffusion method according to the standards of Clinical and Laboratory Standards Institute (CLSI), colistin susceptibility test was performed by Phoenix 100 BD automated system (Becton Dickinson Diagnostic Systems, Sparks). The antibiotic resistance rates of the strains were found to be 18 % for amikacin and piperacillin/tazobactam, 25 % for piperacillin, 28 % for ciprofloxacin, 30 % for imipenem, 32 % for ceftazidim, 35 % for gentamicin, 41 % for sefepim and 91 % for cefotaxime. Colistin resistance was not determined. The results indicated that colistin, amikacin and piperacillin/tazobactam had been more active agents than other antibiotics.
Pseudomonas aeruginosa is an important nosocomial pathogen which causes serious hospital infections and is resistant to many commonly used antibiotics. This study aims to determine the antibiotic resistance of P.aeruginosa strains isolated from bloodstream infections in our hospital. Antibiotic resistance of P.aeruginosa strains isolated from blood cultures in 2008-2009 years were assessed retrospec-tively. The isolates were identified by conventional methods and Phoenix 100 BD automated system (Becton Dickinson Diagnostic Systems, Sparks). Antibiotic susceptibility test was performed by Kirby-Bauer disk-diffusion method according to the standards of Clinical and Laboratory Standards Institute (CLSI), colistin susceptibility test was performed by Phoenix 100 BD automated system (Becton Dickinson Diagnostic Systems, Sparks). The antibiotic resistance rates of the strains were found to be 18 % for amikacin and piperacillin/tazobactam, 25 % for piperacillin, 28 % for ciprofloxacin, 30 % for imipenem, 32 % for ceftazidim, 35 % for gentamicin, 41 % for sefepim and 91 % for cefotaxime. Colistin resistance was not determined. The results indicated that colistin, amikacin and piperacillin/tazobactam had been more active agents than other antibiotics.
Açıklama
Anahtar Kelimeler
Farmakoloji ve Eczacılık
Kaynak
ANKEM Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
25
Sayı
2
