Atlarda Ksilazin-di?azepam-ketami?n Anestezi?k Kombi?nasyonuna Eklenen Propofolün Etki?si?ni?n Araştırılması
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Dosyalar
Tarih
2003 Nisan
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Selçuk Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Bu çalışmanın amacı; atlarda uygulanan ksilazin-diazepam-ketamin anestezik kombinasyonuna propolol ilave ederek, anestezinin indüksiyonunu ve anesteziden uyanma kalitesini düzeltip/düzeltmeyeceğini ve bazı kardiyopulmoner, hematolojik ve biyokimyasal parametreler üzerine olan etkilerini araştırmaktı. Araştırmada toplam 6 adet at yedi gün arayla her iki grupta da kullanıldı. Grup I'de atlara, ksilazin-diazepam-ketamin kombinasyonu, grup Il'de ise, ksilazin-diazepamketamin-propofol kombinasyonu intravenoz uygulandı. Araştırmada, atlara uygulanan son ilaç enjeksiyonundan sonra, anestezi indüksiyon ve anastezi süresi, stemal pozisyona gelme ve ayağa kalkma zamanı ile anestezi induksiyon, anestezi ve analjezi ile uyanma kalitesi belirlendi. Kalp atım sayisi, solunum sayısı, vücut isisi, sistolik, diastolik ve ortalama kan basınçlan; anesteziden önce, anestezi süresince her 5 dakikada bir 30. ikaya kadar ölçüldü. Hematolojik ve biyokimyasal analizler için anesteziden önce ve sonraki 10., 30., 60. ve 90. dakikalarda kan ömekleri alındı. Kardiyopulmoner parametrelerin anestezinin indüksiyonundan sonraki ilk dönemde düştüğü, sonraki dönemlerde ise başlangıç değere ulaştığı gözlendi. Kombinasyona eklenen propofolün geçici hipertansiyon ve solunum depresyonu oluşturduğu tespit edildi. Propofol ilavesinin klinik anestezi parametrelerinde, kısmi olarak olumlu etki oluşturduğu belirlendi. Sonuç olarak, propofolün. atlarda genel anestezi amacıyla kullanılan ksilazin-diazepam-ketamin kombinasyonuna düşük dozlarda propofol ilavesinin, vital parametrelerde önemli bir değişiklik oluşturmadan anestezinin daha güvenli ve kaliteli olduğu düşüncesine varıldı.
The aim of this study was to determine the effects of propofol when added to xylazine-diazepam-ketamine ansesthetic combination in horse anaesthesia by evaluation of some cardiopulmonary, hematological, biochemical and clinical anaesthetic parameters. In this study a total of six horses were used, and horses were treated two times with two anaesthetic drug combinations at seven days interval in random order. in grup 1, horses were treated with xylazine-diazepamketamine, and in grup Il horses were treated with xylazine-diazepam-ketamine-propofol anaesthetic drug combination. In all horses after last drug injection; anaesthesia induction time, anaesthesia time, and recumbency time to sternal and time to standing were recorded Quality of induction, anaesthesia and recovery were evaluated. Heart rate, respiratory rate, body temparature: systolic, diastolic, mean blood pressures were evaluated before anaesthesia (baseline) and after induction of anaesthesia up to 30 minutes in 5 minutes intervals. Also for hematological and biochemical analysis venous blood samp les were collected before and after induction of anaesthesia at 10, 30, 60, 90 minutes. After induction of anaesthesia car diopulmonary parameters were decreased below baseline values in first stage of anaesthesia and then they were reached to baseline values in late stage of anaesthesia. It was observed that when added to xylazine-diazepam-ketamine combination caused transient hypertansion and respiratory depression, and also slightly changed the clinical anaesthetic parameters in good manner it was concluded that propofol when added to xylazine-diazepam-ketamine anaesthetic com bination for anaesthesia of horses produced more safe and adequate anaesthesia without significant changes in vital parameters.
The aim of this study was to determine the effects of propofol when added to xylazine-diazepam-ketamine ansesthetic combination in horse anaesthesia by evaluation of some cardiopulmonary, hematological, biochemical and clinical anaesthetic parameters. In this study a total of six horses were used, and horses were treated two times with two anaesthetic drug combinations at seven days interval in random order. in grup 1, horses were treated with xylazine-diazepamketamine, and in grup Il horses were treated with xylazine-diazepam-ketamine-propofol anaesthetic drug combination. In all horses after last drug injection; anaesthesia induction time, anaesthesia time, and recumbency time to sternal and time to standing were recorded Quality of induction, anaesthesia and recovery were evaluated. Heart rate, respiratory rate, body temparature: systolic, diastolic, mean blood pressures were evaluated before anaesthesia (baseline) and after induction of anaesthesia up to 30 minutes in 5 minutes intervals. Also for hematological and biochemical analysis venous blood samp les were collected before and after induction of anaesthesia at 10, 30, 60, 90 minutes. After induction of anaesthesia car diopulmonary parameters were decreased below baseline values in first stage of anaesthesia and then they were reached to baseline values in late stage of anaesthesia. It was observed that when added to xylazine-diazepam-ketamine combination caused transient hypertansion and respiratory depression, and also slightly changed the clinical anaesthetic parameters in good manner it was concluded that propofol when added to xylazine-diazepam-ketamine anaesthetic com bination for anaesthesia of horses produced more safe and adequate anaesthesia without significant changes in vital parameters.
Açıklama
Anahtar Kelimeler
Ksiazin, Diazepam, Ketamin, Propofol, Anestezi, At
Kaynak
Eurasian Journal of Veterinary Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
19
Sayı
3-4
Künye
Ceylan, C., İpek, H., Hayat, A., Şakar, M., (2003). Atlarda Ksilazin-di̇azepam-ketami̇n Anestezi̇k Kombi̇nasyonuna Eklenen Propofolün Etki̇si̇ni̇n Araştırılması. Eurasian Journal of Veterinary Sciences, 19(3-4), 41-48.
