Assessment of Abnormal Glucose Homeostasis and İnsulin Resistance in Turkish Obese Children and Adolescents

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dc.contributor.authorAtabek, Mehmet Emre
dc.contributor.authorPirgon, Özgür
dc.contributor.authorKurtoğlu, Selim
dc.date.accessioned2020-03-26T17:03:05Z
dc.date.available2020-03-26T17:03:05Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: The worldwide increase in the prevalence of childhood obesity is reaching epidemic proportions and is associated with a dramatic rise in cases of type 2 diabetes. We determined the prevalence of impaired glucose regulation and insulin resistance in obese children and adolescents. Methods: A total of 196 obese children [SD score (SDS) of body mass index (BMI): 2.17 0.03], aged 7–18 years, including 86 male subjects, underwent an oral glucose tolerance test (1.75 g glucose/kg body weight). We used the modified WHO criteria adapted for children for abnormal glucose homeostasis. Homeostasis model assessment was used to estimate insulin resistance in all subjects. The insulin sensitivity index was also determined in subjects. Results: Of the total of 196 obese children, 15 (6.6%) had an abnormal fasting glucose level. Of the 196 obese children, 35 (18%) had impaired glucose tolerance (IGT) and 83 (43%) had insulin resistance. Of the 196 obese children were six (3%) diagnosed with type 2 diabetes. Insulin resistance indices were correlated well with the degree of abnormal glucose tolerance. Conclusions: IGT, insulin resistance and type 2 diabetes are far more common in obese Turkish children than previously thought. Early treatment in obese children and adolescents with IGT constitutes a strategy of reversing the progression to b-cell failure and preventing type 2 diabetes.en_US
dc.identifier.citationAtabek, M. E., Pirgon, Ö., Kurtoğlu, S., (2007). Assessment of Abnormal Glucose Homeostasis and İnsulin Resistance in Turkish Obese Children and Adolescents. Journal Compilation, (9), 304-310. Doi: 10.1111/j.1463-1326.2006.00601.x
dc.identifier.endpage310en_US
dc.identifier.issn0301-0163en_US
dc.identifier.startpage304en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20342
dc.identifier.volume9en_US
dc.identifier.wosWOS:000239630600176en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorAtabek, Mehmet Emre
dc.institutionauthorPirgon, Özgür
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofJournal Compilationen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectChildhood obesity
dc.subjectİmpaired glucose tolerance
dc.subjectİnsulin resistance
dc.subjectType 2 diabetes
dc.titleAssessment of Abnormal Glucose Homeostasis and İnsulin Resistance in Turkish Obese Children and Adolescentsen_US
dc.typeConference Objecten_US

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