Evaluation of direct antiglobulin test positivity in neonates

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dc.contributor.authorKarataş, Zehra
dc.contributor.authorKarataş, Ahmet
dc.contributor.authorAkşit, Mehmet Arif
dc.contributor.authorTekin, Neslihan
dc.date.accessioned2020-03-26T18:22:02Z
dc.date.available2020-03-26T18:22:02Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim: The objective of the present study is to determine clinical, laboratory findings, treatment and prognosis in newborns with positive direct antiglobulin test (DAT). Methods: Ninety-seven patients with positive direct coomb's test from 2362 newborns who were hospitalized in Neonatology Unit of Eskisehir Osmangazi University Faculty of Medicine between June 2004-November 2006 were reviewed retrospectively. Chi-square test was used for statistical analysis. Results: The prevalance of DAT was 4.1%. Twenty-six patients were premature. In 75 patients DAT was positive initially. The initial DATs were negative in 34.6% of prematures and 14% of term newborns. But later, the DATs of all these babies were positive, when they were being followed up in hospital. Hemolysis was determined in 41 patients. There were blood group incompatibilities (ABO:44, Rh:12, ABO and Rh:6) in 62 patients. 67 patients were underwent phototherapy and 52 patients were treated with intravenous immunoglobulin (IVIG). Exchange transfusion was performed in 15 patients. Eventually; neonatal cholestasis devoloped in six patients and ten patients died. Conclusion: The most common etiologic factor in the newborns with positive DAT is blood group incompatibility. IVIG therapy reduces the need for exchange especially in the early diagnosis of ABO hemolytic disease. Prematurity and accompanying systemic inflammatory response syndrome (SIRS) and/or infections may be the causes of positive DAT without immune hemolytic anemia. © 2011 Düzce Medical Journal.en_US
dc.identifier.endpage40en_US
dc.identifier.issn1307671Xen_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage36en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27095
dc.identifier.volume13en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofDuzce Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDirect coomb's testen_US
dc.subjectNewbornen_US
dc.subjectPrematureen_US
dc.titleEvaluation of direct antiglobulin test positivity in neonatesen_US
dc.title.alternativeYenidoğanlarda direkt antiglobülin test pozitifliğinin değerlendirilmesi
dc.typeArticleen_US

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