Development of a spectrofluorimetric method for determination of thiabendazole in tablets

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dc.contributor.authorKucukkolbasi S.
dc.contributor.authorKilic E.
dc.date.accessioned2020-03-26T18:48:12Z
dc.date.available2020-03-26T18:48:12Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn this study a spectrofluorimetric method has been developed for determination of thiabendazole drug active compound in tablets. For this purpose; thiabendazole drug activecompound was measured fluorescence intensities at excitation (?ex) and emission (?em) wavelength in various solvents. Suitable solvent was determined for each compound from calibration graphs and tablets' excipients. Spectrofluorimetric method for the determination of thiabendazole in tablet was described under the optimum conditions. The wavelengths of excitation and emission were 370,0 nm and 428.8 nm respectively. The fluorescence intensity was linearly related to the drug concentration and the method was found to be highly accurate and precise, having a relative standard deviation of less than 0.8 %. This proposed method was applied to the determination of thiabendazole in tablet. The validity of the method was tested by the recovery studies of standard addition to pharmaceuticals and the result was found to be satisfactory. The results compared with official USP 24 HPLC method were in good agreement and statistical comparison by means of Student's t-test and the variance ratio F-test showed no significant difference between the two methods. The proposed method is simple and sufficiently precise for quality control purposes in routine analysis.en_US
dc.identifier.doi10.7324/JAPS.2013.30219en_US
dc.identifier.endpage114en_US
dc.identifier.issn2231-3354en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage109en_US
dc.identifier.urihttps://dx.doi.org/10.7324/JAPS.2013.30219
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30130
dc.identifier.volume3en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Applied Pharmaceutical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDeterminationen_US
dc.subjectPharmaceuticalsen_US
dc.subjectSpectrofluorimetryen_US
dc.subjectThiabendazoleen_US
dc.titleDevelopment of a spectrofluorimetric method for determination of thiabendazole in tabletsen_US
dc.typeArticleen_US

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