Ghrelin, resistin and leptin levels in patients with metabolic syndrome
Küçük Resim Yok
Tarih
2011
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmada metabolik sendromlu (MS) hastalar ile sağlıklı kontroller arasında açlık ghrelin, leptin ve resistin düzeylerinin karşılaştırılması amaçlanmıştır. Metod: Çalışmaya 21 MS hastası (7 erkek; ortalama yaş, 444) ve 17 sağlıklı kontrol (8 erkek; ortalama yaş 433) alınmıştır. MS tanısı Ulusal Kolesterol Eğitim Programı (NCEP) Erişkin Tedavi Paneli (ATP) III kriterlerine göre tanımlandı. MS karşılama kriterlerinden en az 3’üne sahip olan ve beden kitle indeksi (BKI) 30 kg/m² olan hastalar MS grubuna seçildi. Sağlıklı gönüllüler arasında BKI 30 kg/m² olanlar kontrol grubu olarak seçildi. Plazma ghrelin, leptin ve resistin düzeyleri ELISA yöntemi ile ölçüldü. Bulgular:Ghrelin düzeyleri MS ve kontrol grupları arasında benzerdi. Ghrelin ve Leptin seviyeleri ile BKİ arasında negatif bir ilişki tespit edildi (r-.54, P.01 ve r-.56, p 0.009, sırasıyla). Resistin düzeyleri kontrol grubu ile MS arasında benzer bulundu. Leptin düzeyleri kontrol grubuna göre MS grubunda (3517 ng/ml ve 148 ng/ml, p 0.001) anlamlı derecede daha yüksek bulundu. Leptin düzeyleri ile BKİ arasında pozitif korelasyon vardı (r 0.56; p 0.008). Biz MS grubunda leptin düzeylerinin kontrol grubuna göre daha yüksek olduğunu gösterdik. Ancak, ghrelin ve resistin düzeyleri kontrol grubuna benzerdi. Sonuç: Sonuç olarak biz leptin düzeyleri ile BKİ arasında pozitif bir ilişki olduğunu ve ghrelin seviyeleri ile negatif ilişkili olduğunu gösterdik.
Aim: This study was designed to compare the fasting ghrelin, leptin and resistin levels between metabolic syndrome (MS) patients with healthy controls. Method: This trial was performed on 21 patients with MS (7 men; mean age, 44±4 years) and 17 healthy controls (8 men; mean age, 43±3 years). Diagnosis of MS was defined based on National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III criteria. Patients meeting at least 3 of the MS criteria, with a body mass index (BMI) &#8805;30 kg/m² were included in the MS group. Among healthy volunteers, those with a BMI<30 kg/m² were selected as the control group. Plasma ghrelin, serum leptin and resistin concentrations were measured by ELISA method. Result: Ghrelin levels were similar between MS and control groups. There was a negative correlation detected between ghrelin levels with BMI and leptin levels (r-.54, P.01 and r-.56, P.009, respectively). Resistin levels were found similar between MS with control groups. Leptin levels were significantly higher at the MS group than control group (35±17 ng/ml vs. 14±8 ng/ml, P.001). Leptin levels had a positive correlation with BMI (r.56; P.008). Conclusion: We have demonstrated that leptin levels in MS group were higher than control group. However, ghrelin and resistin levels were similar to control group. In addition, we have showed leptin levels has a positive correlation with BMI and a negative correlation with ghrelin levels.
Aim: This study was designed to compare the fasting ghrelin, leptin and resistin levels between metabolic syndrome (MS) patients with healthy controls. Method: This trial was performed on 21 patients with MS (7 men; mean age, 44±4 years) and 17 healthy controls (8 men; mean age, 43±3 years). Diagnosis of MS was defined based on National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III criteria. Patients meeting at least 3 of the MS criteria, with a body mass index (BMI) &#8805;30 kg/m² were included in the MS group. Among healthy volunteers, those with a BMI<30 kg/m² were selected as the control group. Plasma ghrelin, serum leptin and resistin concentrations were measured by ELISA method. Result: Ghrelin levels were similar between MS and control groups. There was a negative correlation detected between ghrelin levels with BMI and leptin levels (r-.54, P.01 and r-.56, P.009, respectively). Resistin levels were found similar between MS with control groups. Leptin levels were significantly higher at the MS group than control group (35±17 ng/ml vs. 14±8 ng/ml, P.001). Leptin levels had a positive correlation with BMI (r.56; P.008). Conclusion: We have demonstrated that leptin levels in MS group were higher than control group. However, ghrelin and resistin levels were similar to control group. In addition, we have showed leptin levels has a positive correlation with BMI and a negative correlation with ghrelin levels.
Açıklama
Anahtar Kelimeler
Cerrahi
Kaynak
European Journal of General Medicine
WoS Q Değeri
Scopus Q Değeri
Cilt
8
Sayı
2
