Effect of Tilmicosin on Serum Cytokine Levels in the Endotoxemia

Basit Öğe Kaydı
dc.contributor.authorUney, Kamil
dc.contributor.authorEr, Ayse
dc.contributor.authorAvci, Gulcan Erbil
dc.contributor.authorBulbul, Aziz
dc.contributor.authorElmas, Muammer
dc.contributor.authorYazar, Enver
dc.date.accessioned2020-03-26T17:38:23Z
dc.date.available2020-03-26T17:38:23Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe effect of tilmicosin on serum cytokine concentrations were investigated in healthy and lipopolysaccharide-treated mice. The mice were divided into 3 groups. Lipopolysaccharide (250 mu g, Escherichia coli 0111:B4, intraperitoneally) was injected into the positive control group. The other 2 groups received tilmicosin (20 mg kg(-1), subcutaneously) concurrently without or with lipopolysaccharide. After treatment, serum samples were collected at 0, 1.5, 3, 6, 12 and 24 h. Serum tumor necrosis factor, interleukin-1 and interleukin-10 levels were determined by enzyme-linked immunosorbent assay. Lipopolysaccharide increased all cytokine levels in the healthy mice. Tilmicosin slightly induced interleukin-1 production in the healthy mice, while it had no effect on tumor necrosis factor or interleukin-10 productions. However, tilmicosin elevated (p<0.05) tumor necrosis factor, interleukin-1 and interleukin-10 levels in lipopolysaccharide-treated mice. In conclusion, these data suggest that tilmicosin stimulates both proinflammatory and antiinflammatory cytokines at the dose recommended for infection.en_US
dc.identifier.endpage1024en_US
dc.identifier.issn1680-5593en_US
dc.identifier.issue5en_US
dc.identifier.startpage1021en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23464
dc.identifier.volume8en_US
dc.identifier.wosWOS:000265889000037en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherMEDWELL ONLINEen_US
dc.relation.ispartofJOURNAL OF ANIMAL AND VETERINARY ADVANCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectTilmicosinen_US
dc.subjectlipopolysaccharideen_US
dc.subjectTNFen_US
dc.subjectIL-1en_US
dc.subjectIL-10en_US
dc.titleEffect of Tilmicosin on Serum Cytokine Levels in the Endotoxemiaen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu