The effects of ankaferd blood stopper on DNA damage and enzymes with paranchymal damaged rabbits

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dc.contributor.authorMetin, Bayram
dc.contributor.authorMenevşe, Esma
dc.contributor.authorSivrikaya, Abdullah
dc.contributor.authorAltınok, Tamer
dc.contributor.authorArıkoğlu, Hilal
dc.date.accessioned2020-03-26T19:32:43Z
dc.date.available2020-03-26T19:32:43Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAnkaferd blood stopper (ABS) is a medical product that is used in several injuries, dental operations, prevention of minor or major bleeding after spontaneous or surgerical operations and have anti-microbial, anti-inflamatory, anti-thrombin, anti-platelet, anti-atherosclerotic, anti-oxidants effects. The present study is aimed to evaluate the effects of ABS on 8-hydroxy-2?-deoxyguanosine (8-OHdG), superoxide dismutase (SOD), myeloperoxidase (MPO) levels over pleural adhesions in rabbits with pulmonary parenchymal damage.16 New Zelland species rabbits were divided in two groups such as control (n7) and study group (n7). One rabbit in each group died during anesthesia. In both groups, we performed wedge resections in equal size to the left lower lobes of all rabbits. No interventions were made on control group, whereas 5 puff’s (1 cc) ABS was performed to the resection area at study group. Tube thoracostomy that performed both groups were terminated postoperatively at 6th hour after drainage and air leakages follow up. Rabbits were sacrificed with anesthetics at postoperative 8th day. Lung tissues were collected for analyzing of 8-OHdG, SOD, MPO. The 8-OHdG levels were respectively 2.010.39 ng/ml in control group and, 0.380.12 ng/ml in study. The differences between study and control group were statistically important group (p0.001). SOD and MPO levels did not show any statistically importance in the groups. As a conclusion, we can say that oxidative DNA damage prevented by ABSen_US
dc.identifier.endpage10en_US
dc.identifier.issn2147-0634en_US
dc.identifier.issn2147-0634en_US
dc.identifier.issue1en_US
dc.identifier.startpage5en_US
dc.identifier.urihttp://www.trdizin.gov.tr/publication/paper/detail/TWpZek56VTVPUT09
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34543
dc.identifier.volume6en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofMedicine Scienceen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectGenel ve Dahili Tıpen_US
dc.titleThe effects of ankaferd blood stopper on DNA damage and enzymes with paranchymal damaged rabbitsen_US
dc.typeArticleen_US

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