Kronik Böbrek Yetmezliği Olan Hastaların Periodontal Durumlarının ve Polimorfonükleer Lökositlerin Fagositik Aktivitelerinin İncelenmesi
Küçük Resim Yok
Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Kronik Böbrek Yetmezliği (KBY) olan hastalarda hücresel ve humoral immün sisteme ait bazı bozukluklar vardır. Polimorfonükleer lökositler (PMNL), bakteriyel enfeksiyonlara karşı konağın ilk savunma hattını oluştururlar. Bu çalışmada KBY teşhisi konulmuş ve hemodiyaliz tedavisi gören hastalar ile sistemik olarak sağlıklı olup periodontitisi olan, gingivitisi olan ve periodontal olarak da sağlıklı bireylerin klinik periodontal özellikleri ile bu bireylerin PMNL'lerinin fagositik aktivitelerinin in vitro olarak incelenmesi amaçlandı. Çalışma, KBY teşhisi konulmuş ve hemodiyaliz tedavisi gören 9 hasta, sistemik problemi olmayan ancak periodontitisi olan 9 hasta ve gingivitisi olan 9 hasta ile periodontal olarak sağlıklı olan 9 birey olmak üzere toplam 36 birey üzerinde yürütüldü. Araştırmaya dahil edilen bireylerde periodontal yapının değerlendirilmesi amacıyla; Sondalama Cep Derinliği (SCD), Klinik Ataşman Seviyesi (KAS), Gingival indeks (Gl) ve Plak indeksi (Pl) ölçümleri yapıldı. Ayrıca, KBY olan hastaların he-modiyalize girdikleri süreler kaydedildi. PMNL'lerin fagositik aktivitesi, venöz kandan izole edilen nötrof illerin Candida albicans'ı in vitro olarak fagosite etme oranlarına göre belirlen-di. Fagositoz yeteneğine sahip nötrof illerin yüzde oranları ve nötrofillerin fagosite ettikleri Candida albicans ortalamaları en yüksek sağlıklı grupta saptanırken (P0.05), hemodiyaliz tedavisi gören hastalar ile periodontitisi ve gingivitisi olan hastalarda bu oran daha düşüktü (P0.05). KBY olan hastalarda nötrofillerin fagositik aktivite defekt oranlan ile bu hastaların diyaliz süreleri arasında herhangi bir ilişkiye rast-lanamadı. Bu çalışmanın sonuçlarına göre, hemodiyaliz tedavisi gören hastalarda PMNL'lerin fagositik aktivitesindeki azalmanın, KBY olan hastalara özgü olmayabileceği düşünülür.
Patients uıith Chronic Renal Failure (CRF) have immunological defects due to cellular and humoral disorders. Polymorphonuclear Leucocytes (PMNs) are corside edlo-be an initial host defense barrier against periodontal bacterial infections. Preseni study aims to compare the clinical periodontal status and in vitro phagocytic activity of PMNs. in this study, the investigation of in vitro pha-gocytic activitiys in PMN of CRFpatients receiving hemo-dia/ysis, systemically healthy patients with periodontitis ör gingiuitis and periodontally healthy subjects. The study groups were as follouıs; 9 patients diagnosed as CRF and receiving hemodialysis, 9 systemically healthy patients uıith periodontitis, 9 systemically healthy patients uıith gingivitis and 9 periodontally healthy individuals. Periodontal status of subjects in the study as clinically evaluated by clinical attachment level (ÇAL), probing depth (PD), gingival index (Gl), and plaque index (Pl). The duration of receiving hemodialysis in patients with CRF uıas recorded. Venous blood samples uıere drauın from ali the subjects and the evaluation uıere based on in vitro phagocytic ability of peripheral PMN's by uptake of Candida albicans. While the ratio of neutrophils which are capable of phagocytosis was the highest in the healthy group (p< 0.05), the ratio of these neutrophils among CRF, periodontitis and gingivitis patients were not statistically significant (p>0.05). in patients with CRF, there was no correlation betuıeen the phagocytic activity of the neutrophils and the duration of hemodialysis. According to the results of this study, it is suggested that in patients with periodontal disease the decrease in the phagocytic activitiy of PMN's, may be not specific to CRF patients receiving hemodialysis.
Patients uıith Chronic Renal Failure (CRF) have immunological defects due to cellular and humoral disorders. Polymorphonuclear Leucocytes (PMNs) are corside edlo-be an initial host defense barrier against periodontal bacterial infections. Preseni study aims to compare the clinical periodontal status and in vitro phagocytic activity of PMNs. in this study, the investigation of in vitro pha-gocytic activitiys in PMN of CRFpatients receiving hemo-dia/ysis, systemically healthy patients with periodontitis ör gingiuitis and periodontally healthy subjects. The study groups were as follouıs; 9 patients diagnosed as CRF and receiving hemodialysis, 9 systemically healthy patients uıith periodontitis, 9 systemically healthy patients uıith gingivitis and 9 periodontally healthy individuals. Periodontal status of subjects in the study as clinically evaluated by clinical attachment level (ÇAL), probing depth (PD), gingival index (Gl), and plaque index (Pl). The duration of receiving hemodialysis in patients with CRF uıas recorded. Venous blood samples uıere drauın from ali the subjects and the evaluation uıere based on in vitro phagocytic ability of peripheral PMN's by uptake of Candida albicans. While the ratio of neutrophils which are capable of phagocytosis was the highest in the healthy group (p< 0.05), the ratio of these neutrophils among CRF, periodontitis and gingivitis patients were not statistically significant (p>0.05). in patients with CRF, there was no correlation betuıeen the phagocytic activity of the neutrophils and the duration of hemodialysis. According to the results of this study, it is suggested that in patients with periodontal disease the decrease in the phagocytic activitiy of PMN's, may be not specific to CRF patients receiving hemodialysis.
Açıklama
Anahtar Kelimeler
Diş Hekimliği
Kaynak
Hacettepe Dişhekimliği Fakültesi Derg.(. Clinical Dentistry and Research)
WoS Q Değeri
Scopus Q Değeri
Cilt
27
Sayı
1
Künye
Duran, İ., Baş, A. L., Özgür, Z., Alptekin, N. Ö., (2003). Kronik Böbrek Yetmezliği Olan Hastaların Periodontal Durumlarının ve Polimorfonükleer Lökositlerin Fagositik Aktivitelerinin İncelenmesi. Hacettepe Dişhekimliği Fakültesi Derg.(. Clinical Dentistry and Research), 27(1), 9-16.
