Effect of different selenium levels on thyroid hormone synthesis

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dc.contributor.authorBal, Ceylan
dc.contributor.authorBüyükşekerci, Murat
dc.contributor.authorErcan, Müjgan
dc.contributor.authorHocaoğlu, Asım
dc.contributor.authorÇelik, Hüseyin Tuğrul
dc.contributor.authorAbuşoğlu, Sedat
dc.contributor.authorTutkun, Engin
dc.contributor.authorYılmaz, Ömer Hınç
dc.date.accessioned2020-03-26T19:08:15Z
dc.date.available2020-03-26T19:08:15Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: As an essential element, selenium is very important for thyroid functions. Iodothyronine deiodinase-I is a selenium containing enzyme that is responsible for production of triiodothyronine (T3) from thyroxin (T4) in peripheral tissues. The aim of this study is to investigate the effect of different levels of selenium on thyroid hormone synthesis. Methods: 303 participants who had admitted to several clinics of Ankara Occupational Diseases Hospital and whose serum thyroid hormone and selenium levels were determined between years 2012 and 2014 were separated into 3 groups according to serum selenium levels. Group 1: 50-75?g/L, group 2: 75,1-100?g/L, group 3: 100,1-125?g/L. The thyroid stimulating hormone (TSH), free T3 (FT3) and free T4 (FT4) levels of groups were compared with each other. Results: There was statistically non-significant difference among 3 groups concerning the serum TSH and FT3 levels (p=0,91; p=0,18). Group 3 serum FT4 levels were lower than other groups. FT4 levels of group 3 were significantly different from group 1 (p= 0,005). T3/T4 ratio was significantly higher in group 3 than other groups (p=0,004). There was a negative correlation between selenium and FT4 levels (r=-0,184; p=0,001), whereas a positive correlation existed between selenium and T3/T4 ratio (r=0,178, p=0,002). Conclusion: Selenium has an important role in thyroid functions and FT4 levels increase in selenium deficiency. High FT4 levels should be considered in low selenium levels.en_US
dc.identifier.doi10.5505/TurkHijyen.2015.17037en_US
dc.identifier.endpage316en_US
dc.identifier.issn0377-9777en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage311en_US
dc.identifier.urihttps://dx.doi.org/10.5505/TurkHijyen.2015.17037
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32808
dc.identifier.volume72en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherRefik Saydam National Public Health Agency (RSNPHA)en_US
dc.relation.ispartofTurk Hijyen ve Deneysel Biyoloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectIodothyronine deiodinase Ien_US
dc.subjectSeleniumen_US
dc.subjectThyroid hormonesen_US
dc.titleEffect of different selenium levels on thyroid hormone synthesisen_US
dc.typeArticleen_US

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