İktiyoziform mikozis fungoides: Mikozis fungoidesin nadir görülen atipik bir varyantı
Küçük Resim Yok
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Mikozis fungoides (MF) en sık görülen kütanöz T hücreli lenfoma olup epidermotropizm gösteren atipik T hücrelerinin deride klonal artışı ile karakterizedir. MF’nin yama, plak ve tümörlerle seyreden klasik ‘Alibert-Bazin’ tipi dışında birçok subtipi ve klinik varyantı vardır. İlk kez 1996 yılında tanımlanan ve MF’in nadir bir klinik formu olarak değerlendirilen İktiyoziform MF (IMF), MF’nin klinikopatolojik spektrumu içerisinde yer almaktadır. Folikülotropik MF lezyonlarıyla birlikte olma eğiliminde olup MF’nin nispeten benign seyirli bir formudur. İktiyoziform MF, kütanöz lenfomalarla ilişkili diğer akkiz iktiyozlardan farklı bir tablodur. Lenfoma ilişkili akkiz iktiyozda iktiyotik alandaki biyopsi örneğinde lenfomayı düşündürecek bir bulgu bulunmaz ancak iktiyoziform MF’de biyopsi örneği hem iktiyoza hem de MF’e ait histolojik özellikler gösterir. Olgu sunumu: Polikliniğimize iktiyotik lezyonlarla başvuran ve iktiyoziform MF tanısı konan bu vakayı MF’nin nadir bir formu olması nedeniyle sunmayı uygun bulduk. Sonuç: İktiyotik erupsiyonlar; çok farklı özellikteki hastalıkların bir bulgusu olabileceğinden klinikopatolojik değerlendirmede MF'nin de akla gelmesi tanısal olarak uygun bir yaklaşım olacaktır.
Objective: Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma and characterized by clonal increase of atypical T-cells in the skin showing epidermotropism. MF has many subtypes and clinical variants along with the classical Alibert-Basin type characterized by patches, plaques and tumors. Ichthyosiform MF, first defined in 1996 and considered as a rare clinical form of MF, is included in clinicopathologic spectrum of MF and is a comparatively benign form of MF which tends to be together with folliculotropic MF lesions. Ichthyosiform MF is a different condition when compared to other acquired ichthyoses associated with cutaneous lymphomas. A biopsy specimen taken from the ichthyotic area of acquired ichthyosis associated with lymphomas does not indicate a finding suggestive of lymphoma, nevertheless biopsy specimen taken from ichthyosiform MF lesions shows histological features of both MF and ichthyosis. Case report: Here, we present this case which has visited to our polyclinic with ichthyotic lesions and is diagnosed with ichthyosiform MF due to the fact that it is a rare form of MF. Conclusion: Ichthyotic eruption can be a finding of diseases which have very different features. So, it will be a convenient approach to consider MF in this clinico-pathologic evaluation.
Objective: Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma and characterized by clonal increase of atypical T-cells in the skin showing epidermotropism. MF has many subtypes and clinical variants along with the classical Alibert-Basin type characterized by patches, plaques and tumors. Ichthyosiform MF, first defined in 1996 and considered as a rare clinical form of MF, is included in clinicopathologic spectrum of MF and is a comparatively benign form of MF which tends to be together with folliculotropic MF lesions. Ichthyosiform MF is a different condition when compared to other acquired ichthyoses associated with cutaneous lymphomas. A biopsy specimen taken from the ichthyotic area of acquired ichthyosis associated with lymphomas does not indicate a finding suggestive of lymphoma, nevertheless biopsy specimen taken from ichthyosiform MF lesions shows histological features of both MF and ichthyosis. Case report: Here, we present this case which has visited to our polyclinic with ichthyotic lesions and is diagnosed with ichthyosiform MF due to the fact that it is a rare form of MF. Conclusion: Ichthyotic eruption can be a finding of diseases which have very different features. So, it will be a convenient approach to consider MF in this clinico-pathologic evaluation.
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp
Kaynak
Genel Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
21
Sayı
3
