Role of tenoxicam in the prevention of postlaminectomy peridural fibrosis in rats [Ratlarda laminektomi sonrasi{dotless} peridural fibrozisin önlenmesinde tenoksikami{dotless}n rolü]

Basit Öğe Kaydı
dc.contributor.authorKaratay M.
dc.contributor.authorCelik H.
dc.contributor.authorKoktekir E.
dc.contributor.authorKaratay E.
dc.contributor.authorSertbas I.
dc.contributor.authorYilmaz A.
dc.contributor.authorCaydere M.
dc.date.accessioned2020-03-26T18:44:49Z
dc.date.available2020-03-26T18:44:49Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim: The reason behind failed back syndrome in some cases may be peridural fibrosis following spinal surgery. Many attempts have been shown to stop formation of peridural fibrosis. Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the inflammatory and fibroblastic response. One of the most effective nonsteroidal anti-inflammatory drugs is tenoxicam, an oxicam derivative. This study suggests that topical application of tenoxicam is an effective way of preventing spinal peridural fibrosis developing after laminectomy in rats. Material and Methods: In this study, 20 Wistar rats were used. Rats were divided into two groups; a control group, and a tenoxicam group. Three-level laminectomy was implemented on the rats. Rats in the control group only had the laminectomy. In the tenoxicam group, 0.5 mg/kg tenoxicam, which was watered down in 0.9% NaCl with a factor of 1:10 soaked on cotton, was applied on the dura topically for 5 minutes. Three weeks later, rats were killed for histopathologic examination and peridural fibrosis tissue was classified afterwards. Results: Statistically, it was found that three weeks after surgery, the tenoxicam group had significantly less peridural fibrosis compared to the control group (p<0.05). Conclusion: Tenoxicam significantly reduced the spinal peridural fibrosis that developed in rats after laminectomy.en_US
dc.identifier.endpage565en_US
dc.identifier.issn1300-1817en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage559en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30056
dc.identifier.volume30en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Neurological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectLaminectomyen_US
dc.subjectPeridural fibrosisen_US
dc.subjectTenoxicamen_US
dc.titleRole of tenoxicam in the prevention of postlaminectomy peridural fibrosis in rats [Ratlarda laminektomi sonrasi{dotless} peridural fibrozisin önlenmesinde tenoksikami{dotless}n rolü]en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu