The effects of nitroglycerin in the zone of stasis in a rat burn model [Sıçanlarda deneysel yanık modelinde oluşan staz zonunda nitrogliserinin etkisi]

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dc.contributor.authorGündüz M.
dc.contributor.authorSekmenli T.
dc.contributor.authorUğurluoğlu C.
dc.contributor.authorÇiftçi İ.
dc.date.accessioned2020-03-26T20:20:38Z
dc.date.available2020-03-26T20:20:38Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBACKGROUND: Studies evaluating the recovery of the zone of stasis is an important issue in burn research. In this study, we aimed to evaluate and compare the efficiency of an anti-ischemic and vasodilatory agent, a topical agent containing 2% nitroglycerin with 1% silver sulfadiazine, and bacitracin-neomycin sulfate in the zone of stasis histomorphologically and immunohistochemically. METHODS: We conducted an experimental study using 30 Wistar-Albino rats, each weighing 250–300 grams. The rats were divided randomly into five groups (six rats in each group). In this study, the “comb model,” which was deemed to be the most appropriate experimental model to produce an injury with predictable zones and was first described by Regas and Erhlich, was used. The following were applied to the zone of stasis after creating a burn model in 0, 24, and 48 hours: topical 2% nitroglycerin, 1% silver sulfadiazine, bacitracin-neomycin sulfate, and Vaseline-lanolin (sham). After 72 hours, biopsies were performed from the zone of stasis and evaluated by histomorphological and immunohistochemical CD 34 (expressed in human endothelial and hematopoietic cells) and D 2–40 (expressed in the endothelium of lymphatic capillaries) methods. The results were evaluated using the chi-square test. RESULTS: Compared with the other groups, a statistically significant difference was found in edema, inflammation, and vascular proliferation in the nitroglycerin group. Significantly more intense staining for CD 34 was found in the nitroglycerin group compared with the other groups. Immunohistochemical staining for D 2-40 was also found statistically significant in the nitroglycerin group (p<0.05). CONCLUSION: A topical containing 2% nitroglycerin increases vascular proliferation in the zone of stasis affects the recovery and may be used as a new agent in burn injury treatment. © 2020 Turkish Association of Trauma and Emergency Surgery.en_US
dc.description.sponsorship16401032-07/10/2015en_US
dc.description.sponsorshipFunding: This study was funded by the Selçuk University Research Projects Fund Committee (16401032-07/10/2015). Ethics Committee Approval: This study protocol was approved by the Selçuk University Medical Faculty Ethics Committee (2015/85-29/09/2015). Peer-review: Internally peer-reviewed. Authorship Contributions: Concept: M.G., İ.Ç.; Design: M.G., T.S., C.U., İ.Ç.; Supervision: M.G.; Fundings: M.G., T.S., C.U., İ.Ç.; Materials: M.G., T.S., C.U.; Data: M.G., C.U.; Analysis: M.G., C.U., İ.Ç.; Literature search: M.G.; Writing: M.G.; Critical revision: M.G., İ.Ç.en_US
dc.identifier.doi10.14744/tjtes.2019.00005en_US
dc.identifier.endpage177en_US
dc.identifier.issn1306696Xen_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage171en_US
dc.identifier.urihttps://dx.doi.org/10.14744/tjtes.2019.00005
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38633
dc.identifier.volume26en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkish Association of Trauma and Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma ve Acil Cerrahi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBurn injuryen_US
dc.subjectNitroglycerinen_US
dc.subjectThe zone of stasisen_US
dc.titleThe effects of nitroglycerin in the zone of stasis in a rat burn model [Sıçanlarda deneysel yanık modelinde oluşan staz zonunda nitrogliserinin etkisi]en_US
dc.typeArticleen_US

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