Adie's Tonic Pupil and Anti-Ganglioside IgG Antibodies

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dc.contributor.authorKeklikoglu, Hava Donmez
dc.contributor.authorBakbak, Berker
dc.contributor.authorSarac, Ozge
dc.date.accessioned2020-03-26T18:23:43Z
dc.date.available2020-03-26T18:23:43Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: The presence of anti-ganglioside IgG antibodies has been reported in the Guillain-Barre Syndrome (GBS) and the Miller-Fisher Syndrome (MFS). Adie's tonic pupil (ATP) is similar to GBS and its variants with the symmetric decrease in reflexes and the mydriasis that is an indicator of a parasympathetic disorder but the relationship between ATP and anti-ganglioside antibodies is unknown. Our aim in this study was to investigate the presence of anti-ganglioside IgG antibodies in patients with ATP. Patients and method: The study group consisted of a total of 20 persons with 10 patients and 10 control subjects. The control group consisted of healthy persons who did not have any problems that could influence the immune system. A neuro-ophthalmological examination was performed in all patients and the presence of anti-ganglioside antibodies in the serum was investigated. Results: Serum anti-ganglioside antibodies were negative in the 3 patients included in the study according to the review of old patient charts. Anti-GD1b, anti-GT1b and anti-GM3 antibodies were positive in 2 and anti-GM3 antibodies in 1 of the 7 patients included in the study after a new diagnosis was made. Anti-ganglioside antibodies were negative in all control group subjects. Conclusion: At least one of the anti-ganglioside antibodies was found to be positive in approximately half of the ATP patients in the acute stage (3 of the 7 acute or subacute stage ATP patients). These results indicate that anti-ganglioside antibodies may play a role in ATP development.en_US
dc.identifier.endpage247en_US
dc.identifier.issn1302-1664en_US
dc.identifier.issue2en_US
dc.identifier.startpage243en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27714
dc.identifier.volume29en_US
dc.identifier.wosWOS:000305266500008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherJOURNAL NEUROLOGICAL SCIENCESen_US
dc.relation.ispartofJOURNAL OF NEUROLOGICAL SCIENCES-TURKISHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPupilen_US
dc.subjecttonic pupilen_US
dc.subjectpolyneuropathyen_US
dc.subjectanisocoriaen_US
dc.subjectauto-immune diseasesen_US
dc.subjectmydriasisen_US
dc.subjectFisher syndromeen_US
dc.titleAdie's Tonic Pupil and Anti-Ganglioside IgG Antibodiesen_US
dc.typeArticleen_US

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