New Prospective Materials for Chemoprevention: Three Phlomis

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dc.contributor.authorUysal, Ahmet
dc.contributor.authorGunes, Erdogan
dc.contributor.authorSarikurkcu, Cengiz
dc.contributor.authorCelik, Handan
dc.contributor.authorDurak, Yusuf
dc.contributor.authorUren, Mehmet Cemil
dc.date.accessioned2020-03-26T19:25:19Z
dc.date.available2020-03-26T19:25:19Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim: Plants are permanent sources of biologically active compounds, used by about 80% of the world population as manufactured drugs. The aims of this paper are to determine the mutagenic and antimutagenic activities of methanol, ethyl acetate and water extracts from Phlomis nissoli (PNM, PNE, PNW) Phlomis pungens var. pungens (PPM, PPE, PPW) and Phlomis armeniaca (PAM, PAE, PAW) against well-known mutagens. Methodology: Mutagenic/antimutagenic activities were determined by Ames test. Results: Extracts of P. nissoli, P. pungens and P. armeniaca were not mutagenic against TA98 and TA100 in the condition both with and without S9 mix. The strongest antimutagenic action was revealed by PNE extract at a dose of 5000 mu g/plate against 2-amino-flourene with 96% inhibition for TA98 with S9 mix. PNM extract alleviated the mutagenic action of 2-amino-anthracene and exhibited strong inhibition rates (93%, 78%, 57%, respectively) with S9 mix at all doses for TA100 strain. While PAE extract manifested 95%, 91% and 84% inhibition against 2-amino-flourene for TA98, it revealed 90%, 84%, and 87% inhibition ratios, respectively, making them as strongly antimutagenic against 2-amino-anthracene for TA100 with S9 mix. Conclusion: P. nissoli, P. pungens and P. armeniaca extracts have significant antimutagenic capacities and they can represent a good model for the development of new drug formulations in pharmaceutical industry and they could be used in food industry as chemoprevention agent.en_US
dc.identifier.doi10.9734/BJPR/2016/23963en_US
dc.identifier.issn2231-2919en_US
dc.identifier.issue3en_US
dc.identifier.pmid#YOKen_US
dc.identifier.urihttps://dx.doi.org/10.9734/BJPR/2016/23963
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33826
dc.identifier.volume10en_US
dc.identifier.wosWOS:000370145200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSCIENCEDOMAIN INTen_US
dc.relation.ispartofBRITISH JOURNAL OF PHARMACEUTICAL RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPhlomis nissolien_US
dc.subjectPhlomis pungens var. pungensen_US
dc.subjectPhlomis armeniacaen_US
dc.subjectantimutagenicityen_US
dc.subjectchlorogenic aciden_US
dc.titleNew Prospective Materials for Chemoprevention: Three Phlomisen_US
dc.typeArticleen_US

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