Determination of the ionization constant of local anaesthetics in organic solvent-water media by the spectrofluorimetric method

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dc.contributor.authorBeniz Gündüz S.
dc.contributor.authorEdiz E.
dc.contributor.authorAltınorduv Z.
dc.date.accessioned2020-03-26T19:08:15Z
dc.date.available2020-03-26T19:08:15Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe ionization constant (pKa) in general is a chief parameter for evaluating and measuring the reaction estimates, biological effects and retention, biological conveyance and ambient consequences. Therefore, the fluorimetric parameters of some local anaesthetics such as dibucaine, procaine and tetracaine in certain percentages of acetonitrile-water and methanol-water mixtures were optimized and then the pH and solvent percentage effects on fluorimetric parameters were investigated. In the optimal excitation and emission wavelengths and solvent percentage, pKa values of these compounds have been determined by plotting the pH-fluorescence intensity graphs in each solvent media. Almost all ionic species of tetracaine and the acidic species of dibucaine and procaine were fluorescent, but the basic species of dibucaine and procaine were non-fluorescent. The pKa values of the local anaesthetics in methanol-water media were very similar to those in acetonitrile-water media. Moreover, the pKa values determined by the spectrofluorimetric method were very close to the values predicted by the SPARC on-line pKa calculator. © 2014 Bentham Science Publishers.en_US
dc.identifier.endpage238en_US
dc.identifier.issn1574-8855en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage232en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32807
dc.identifier.volume9en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBentham Science Publishers B.V.en_US
dc.relation.ispartofCurrent Drug Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectIonization constanten_US
dc.subjectLocal anaestheticsen_US
dc.subjectPKaen_US
dc.subjectSpectrofluorimetric methoden_US
dc.titleDetermination of the ionization constant of local anaesthetics in organic solvent-water media by the spectrofluorimetric methoden_US
dc.typeArticleen_US

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