A new drug delivery system based on magnetic calixarene nanoparticles
Küçük Resim Yok
Tarih
2017
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
American Scientific Publishers
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A new drug carrier platform was design based on magnetic calixarene nanoparticles for drug delivery. For this purpose, a calixarene derivative called compound 6 was synthesized and bounded to [3-(2, 3-epoxypropoxy)propyl]-grafted Fe3O4 nanoparticles (SPIONs) using potassium carbonate in acetonitrile to produce a magnetic platform as a drug carrier. Then, doxorubicin (DOX) was loaded onto these calixarene nanoparticles (CALIX-SPIONs) in Tris buffer of pH 7.4 at a nanoparticle concentration of 5-30 mg. The release studies of DOX were performed using different buffers with a pH of 2.2, 4, 6, and 7.4. The binding amount of DOX was estimated by using fluorescence spectroscopy. The binding studies were confirmed by Fourier transform infrared spectroscopy (FTIR) experiments, as well as SEM, EDX, and TEM analysis. Calixarene based magnetic nanoparticles were successfully designed as a drug carrier platform. Copyright © 2017 American Scientific Publishers All rights reserved.
Açıklama
Anahtar Kelimeler
Calixarene, Doxorubicin, Drug delivery, Nanobioscience, Nanoparticles, SEM, TEM
Kaynak
Journal of Bionanoscience
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
11
Sayı
5
