The effect of furosemide and acetazolamide induced ion trapping phenomena on renal excretion of chemicals
Küçük Resim Yok
Tarih
1998
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info:eu-repo/semantics/openAccess
Özet
Bu deneysel çalışma, zorunlu diürezis ile vücuttan atılımı artırmak için kimyasalların pKa değerine göre diüretik ilaç seçiminin önemini ortaya koymak üzere gerçekleştirildi. Denemede, ağırlıkları 15-20 kg arasında değişen 15 adet köpek kullanıldı. Köpekler Grup I, II ve III olmak üzere üç gruba ayrıldı ve her gruptaki köpeklere 1 ml'sinde 200 mg sülfadoksin ve 40 mg trimetoprim içeren Animar (Roche)'dan İM yolla yüksek dozda injekte edildi. Grup Il'deki hayvanlara Animar enjeksiyonundan 2 saat sonra İM yolla 5 mg/kg dozunda furosemid uygulandı. Üçüncü gruptaki hayvanlara ise Animar uygulamasını takibeden 1. ve 8. saatlerde toplam 200 mg dozunda asetazolamid ikiye bölünerek oral yolla verildi. Toplanan kan ve idrar numunelerindeki sülfadoksin ve trimetoprim konsantrasyonları HPLC yardımı ile belirlendi. Asetazolamidin sülfadoksinin, furosemidin ise trimetoprimin böbrekten atılımı üzerinde daha etkili olduğu gözlendi. Asetazolamid idrar pH'sını önemli, oranda artırırken, furosemid çok az derecede bir düşüşe neden oldu. Bu çalışmanın sonuçları, kimyasalların böbrekten atılımı üzerine, diüretiklerin potansiyel etkilerinden daha çok diğer faktörlerin etkili olabileceğini ortaya koydu.
This experimental study was conducted to determine the importance of diuretic drug selection on the account of pKa values of chemicals to accelerate the elimination from body by hard diuresis. Fifteen healthy dogs weighing between 15-20 kg, were used as materials. Dogs were divided into three groups to be five dogs in each group (Group I, II, HI). Animar® (Roche), which is containing 200mg sulfadoxin and 40 mg trimethoprim in 1 ml, was injected IM as an overdose to all dogs of experiment. Furosemide (Lasix®) was injected IM to the dogs of group II at the dose of 5 mg/kg body weight 2 hours after Animar® injection. Acetazolamide was given to the dogs of group III at the total dose of 300 mg by per oral at the 1st and 8th hours after Animar® injection. The concentrations of sulfadoxin and trimethoprim in all samples were measured by HPLC. Furosemide was found effective on elimination of trimethoprim from the body, while acetazolamide was found effective on elimination of sulfadoxin. Acetazolamide significantly increased the urine pH and furosemide slightly decreased the urine pH. The results of this study showed that the other factors rather than the potential effects of diuretic drug could be more effective on acceleration of renal excretion of chemicals
This experimental study was conducted to determine the importance of diuretic drug selection on the account of pKa values of chemicals to accelerate the elimination from body by hard diuresis. Fifteen healthy dogs weighing between 15-20 kg, were used as materials. Dogs were divided into three groups to be five dogs in each group (Group I, II, HI). Animar® (Roche), which is containing 200mg sulfadoxin and 40 mg trimethoprim in 1 ml, was injected IM as an overdose to all dogs of experiment. Furosemide (Lasix®) was injected IM to the dogs of group II at the dose of 5 mg/kg body weight 2 hours after Animar® injection. Acetazolamide was given to the dogs of group III at the total dose of 300 mg by per oral at the 1st and 8th hours after Animar® injection. The concentrations of sulfadoxin and trimethoprim in all samples were measured by HPLC. Furosemide was found effective on elimination of trimethoprim from the body, while acetazolamide was found effective on elimination of sulfadoxin. Acetazolamide significantly increased the urine pH and furosemide slightly decreased the urine pH. The results of this study showed that the other factors rather than the potential effects of diuretic drug could be more effective on acceleration of renal excretion of chemicals
Açıklama
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Hayvancılık Araştırma Dergisi
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Cilt
8
Sayı
01.Feb
