The Effect of Postmenopausal Hormone Replacement Therapy on Cardiovascular Performance

Basit Öğe Kaydı
dc.contributor.authorÖzdemir, Kurtuluş
dc.contributor.authorÇelik, Çetin
dc.contributor.authorAltunkeser, Bülent Behlül
dc.contributor.authorİçli, Abdullah
dc.contributor.authorAlbeni, Havva
dc.contributor.authorAkyürek, Cemalettin
dc.contributor.authorGök, Hasan
dc.contributor.authorDüzenli, Mehmet Akif
dc.date.accessioned2020-03-26T16:37:28Z
dc.date.available2020-03-26T16:37:28Z
dc.date.issued2001
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractSummary: Postmenopausal hormone replacement therapy (HRT) has usually been evaluated the relationship with atheroscle- rotic disease, whereas its effect on direct cardiac functions hasn't been investigated in detail. This study was planned to investigate the long-term effects of HRT on cardiac functions and exercise performance. Methods: Thirty-six postmenopausal women (mean age: 51 ± 4 years, 39-60 years) were prospectively analyzed with pulsed wave Doppler echocardiography and symptom-limited exercise stress test before HRT (oral 0.625 mg conjugated estrogen and 2.5 mg medroxyprogesteron acetate/day), and at the third and the sixth months. The effect of HRT on left ventricular ejection fraction (EF), early filling velocity (E wave) and late filling velocity (A wave), E wave deceleration time (EDT), E/A ratio, myocardial performance index (MPI), exercise duration and METS changes were examined. Results: HRT did not significantly alter the left ventricular EF. At the third month of HRT, there was an insignificant increase in E wave, EDT, and E/A ratio, whereas an insignificant decrease was noted in MPI (P>0.05). However, at the sixth month of HRT, these changes became significant (68±12 vs. 75 ± 13 cm/s, P<0.01; 171 ±24 vs. 184 ± 14 ms, P<0.01; 1.01±0.23 vs. 1.11±0.27, P<0.01, and 44±9 vs. 39±8%, P<0.001, respectively). On the other hand, exercise duration and exercise METS values showed significant improvements at the third month of IIRT (423± 104 vs. 482±104 s. P<0.001; 8.2±1.7 vs. 9.1±2 METS, P<0.001). These improvements also continued at the sixth month of IIRT. In conclusion, postmenopausal HRT leads to a progressive improvement on left ventricular function parameters, and in parallel, in exercise performance.en_US
dc.identifier.citationÖzdemir, K., Çelik, Ç., Altunkeser, B., İçli, A., Albeni, H., Akyürek, C., Gök, H., Düzenli, A., (2001). The Effect of Postmenopausal Hormone Replacement Therapy on Cardiovascular Performance. European Heart Journal, (22), 48-48. DOI: doi:10.1016/S0378-5122(03)00248-2
dc.identifier.endpage48en_US
dc.identifier.issn0195-668Xen_US
dc.identifier.startpage48en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17626
dc.identifier.volume22en_US
dc.identifier.wosWOS:000170988300175en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorÖzdemir, Kurtuluş
dc.institutionauthorÇelik, Çetin
dc.institutionauthorAltunkeser, Bülent
dc.institutionauthorİçli, Abdullah
dc.institutionauthorAlbeni, Havva
dc.institutionauthorAkyürek, Cemalettin
dc.institutionauthorGök, Hasan
dc.institutionauthorDüzenli, Akif
dc.language.isoenen_US
dc.publisherW B SAUNDERS CO LTDen_US
dc.relation.ispartofEuropean Heart Journalen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleThe Effect of Postmenopausal Hormone Replacement Therapy on Cardiovascular Performanceen_US
dc.typeConference Objecten_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
10.1016@s0378-51220300248-2.pdf
Boyut:
134.84 KB
Biçim:
Adobe Portable Document Format
Açıklama:
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Kadın Hastalıkları ve Doğum/Makale Koleksiyonu